{"id":"W2783439822","doi":"10.1002/cncr.31218","title":"Phase 1 trial evaluating cisplatin, gemcitabine, and veliparib in 2 patient cohorts: Germline <i>BRCA</i> mutation carriers and wild‐type <i>BRCA</i> pancreatic ductal adenocarcinoma","year":2018,"lang":"en","type":"article","venue":"Cancer","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":103,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Cancer Institute; National Institutes of Health; Lustgarten Foundation","keywords":"Medicine; Gemcitabine; Veliparib; BRCA mutation; Internal medicine; Oncology; Cohort; Pancreatic cancer; Neutropenia; Cisplatin; Cancer; Chemotherapy; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003397329,0.001522592,0.002083529,0.0004286675,0.0006550037,0.001003199,0.0009062384,0.001453358,0.002602872],"category_scores_gemma":[0.001735857,0.0008663037,0.001484756,0.0003663403,0.00119127,0.0008386101,0.0005657136,0.003498438,0.0004349507],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001316622,"about_ca_system_score_gemma":0.002223638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007752159,"about_ca_topic_score_gemma":0.001698293,"domain_scores_codex":[0.9990496,0.0005224849,0.00005417738,0.0001839255,0.00007703229,0.0001127299],"domain_scores_gemma":[0.9983499,0.0003458729,0.0003542344,0.000116913,0.00009527864,0.0007378719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8517831,0.07315746,0.02368661,0.0003081529,0.001313496,0.0003169605,0.0003444469,0.002104626,0.02330331,0.0001900892,0.001884094,0.02160762],"study_design_scores_gemma":[0.6006196,0.3751416,0.01660386,0.00002599533,0.0006462382,0.0004818056,0.00008949734,0.001485016,0.003293742,0.0002023533,0.00137553,0.00003476013],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971835,0.0004125936,0.0002099957,0.0002529394,0.00004268845,0.001152439,0.0004102455,0.00001702108,0.0003184864],"genre_scores_gemma":[0.9916189,0.0005186658,0.001613766,0.0006618995,0.0001570257,0.002772913,0.001761398,0.00001539511,0.0008801159],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003397329,"threshold_uncertainty_score":0.01796705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04547201785071285,"score_gpt":0.3965807012139392,"score_spread":0.3511086833632264,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}