{"id":"W2783448099","doi":"10.1038/s41374-017-0005-4","title":"SLC26A3 (DRA) prevents TNF-alpha-induced barrier dysfunction and dextran sulfate sodium-induced acute colitis","year":2018,"lang":"en","type":"article","venue":"Laboratory Investigation","topic":"Barrier Structure and Function Studies","field":"Neuroscience","cited_by":54,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia; BC Children's Hospital","funders":"Medizinischen Hochschule Hannover; National Natural Science Foundation of China","keywords":"Tight junction; Barrier function; Colitis; Claudin; Tumor necrosis factor alpha; Occludin; Gene knockdown; Immunoprecipitation; Chemistry; Intestinal mucosa; Intestinal epithelium; Molecular biology; Cell biology; Epithelium; Biology; Immunology; Medicine; Biochemistry; Antibody; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002521284,0.0003196548,0.0002780491,0.0001659968,0.0009112945,0.0001599694,0.0001597114,0.0002151674,0.0001037227],"category_scores_gemma":[0.0004191277,0.0003093012,0.00004544617,0.0008100095,0.0004424204,0.0008876704,0.00007700488,0.0002700685,0.0001090543],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007917035,"about_ca_system_score_gemma":0.0001828543,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003314006,"about_ca_topic_score_gemma":0.00008155221,"domain_scores_codex":[0.9977105,0.0003150104,0.0003955217,0.0007387828,0.0004300362,0.0004101923],"domain_scores_gemma":[0.9986877,0.00008785149,0.0002318841,0.0003786414,0.0002936795,0.0003202345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008604231,0.00001176224,0.003036808,0.00002066491,0.00003392039,0.000008050961,0.001165897,2.461565e-7,0.9904515,0.001946872,0.001218999,0.002019296],"study_design_scores_gemma":[0.0009550813,0.0003528145,0.06123232,0.00003200057,0.00009344431,0.00001843727,0.00015111,0.0001093193,0.927208,0.00366485,0.005821044,0.0003615666],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995212,0.00003360608,0.0001694451,0.0005107675,0.002244728,0.0004421992,0.00009704766,0.0002552298,0.001034988],"genre_scores_gemma":[0.9955929,0.00002975368,0.0001447783,0.003151509,0.0006142684,0.00007109858,0.00001383551,0.00004027221,0.000341584],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06324343,"threshold_uncertainty_score":0.9999359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03020322375548719,"score_gpt":0.2613165700345573,"score_spread":0.2311133462790702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}