{"id":"W2783462370","doi":"10.3389/fimmu.2017.01849","title":"Alkaline pH Promotes NADPH Oxidase-Independent Neutrophil Extracellular Trap Formation: A Matter of Mitochondrial Reactive Oxygen Species Generation and Citrullination and Cleavage of Histone","year":2018,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs; Fundação de Amparo à Pesquisa do Estado de São Paulo; Cystic Fibrosis Canada","keywords":"Ionomycin; Neutrophil extracellular traps; Chemistry; Citrullination; NADPH oxidase; Calcium; Extracellular; Biochemistry; Reactive oxygen species; Intracellular; Molecular biology; Biology; Immunology; Citrulline; Inflammation; Arginine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001317736,0.0003023772,0.000229021,0.00008829576,0.0000880369,0.0001929582,0.0001106246,0.0002385708,0.001256574],"category_scores_gemma":[0.0001404552,0.00009304685,0.0002398688,0.00005780458,0.0001505493,0.0002130616,0.0002521668,0.0003687364,0.0001552667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001129559,"about_ca_system_score_gemma":0.0001442663,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002334032,"about_ca_topic_score_gemma":0.0003636577,"domain_scores_codex":[0.999879,0.0000252502,0.00001041324,0.00002114214,0.00003053145,0.00003369213],"domain_scores_gemma":[0.9999169,0.00001745093,0.00002517817,0.000007404318,0.00001067993,0.00002230201],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003864624,0.00003820984,0.000255815,0.00006809951,0.00000600616,0.00008521366,0.00001807413,0.00002370411,0.9978862,0.00003941982,0.0000358695,0.001156926],"study_design_scores_gemma":[0.00004584973,0.000988021,0.008613087,0.00001037795,0.00001841414,0.0003563414,0.00003827077,0.0003958558,0.9880282,0.00006551394,0.00143597,0.000004231817],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9901235,0.005014117,0.002931271,0.0002256442,0.00007046568,0.00004604852,0.0002173348,0.00004368626,0.001328017],"genre_scores_gemma":[0.9958214,0.001237105,0.001359027,0.00008710335,0.00003443261,0.0000334256,0.0001845179,0.000005536649,0.001237485],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001256574,"threshold_uncertainty_score":0.004203677,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332399475777889,"score_gpt":0.2333141324997061,"score_spread":0.2199901377419272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}