{"id":"W2783462370","doi":"10.3389/fimmu.2017.01849","title":"Alkaline pH Promotes NADPH Oxidase-Independent Neutrophil Extracellular Trap Formation: A Matter of Mitochondrial Reactive Oxygen Species Generation and Citrullination and Cleavage of Histone","year":2018,"lang":"en","type":"article","venue":"Frontiers in Immunology","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":110,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; Mitacs; Fundação de Amparo à Pesquisa do Estado de São Paulo; Cystic Fibrosis Canada","keywords":"Ionomycin; Neutrophil extracellular traps; Chemistry; Citrullination; NADPH oxidase; Calcium; Extracellular; Biochemistry; Reactive oxygen species; Intracellular; Molecular biology; Biology; Immunology; Citrulline; Inflammation; Arginine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002130187,0.0002275601,0.0005266172,0.0004136679,0.000126819,0.000009525537,0.0001507379,0.0003440583,0.000134984],"category_scores_gemma":[0.00003753266,0.000219484,0.00005485831,0.0001624013,0.0008398672,0.0002848132,0.00009126775,0.0002484876,0.0000140433],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007395648,"about_ca_system_score_gemma":0.00003476445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000689439,"about_ca_topic_score_gemma":0.00004056015,"domain_scores_codex":[0.9983936,0.0003117413,0.0005934846,0.0003657689,0.00005913018,0.0002762631],"domain_scores_gemma":[0.9991413,0.0000403609,0.0003815019,0.0002556294,0.0001634606,0.00001773244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006529404,0.0001441041,0.0004334764,0.00003816326,0.0001636588,0.00000470232,0.001837359,5.014847e-7,0.9918289,0.001465753,0.001504017,0.001926446],"study_design_scores_gemma":[0.002551694,0.0008348756,0.008021107,0.00004483634,0.00005848179,0.00007463646,0.000784668,0.00004149797,0.9833838,0.001040827,0.002970431,0.0001931601],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9789475,0.005455623,0.0131744,0.0003481447,0.001297371,0.0005085696,0.00005155054,0.00001648507,0.0002003935],"genre_scores_gemma":[0.9944513,0.0003863626,0.004064917,0.00004648092,0.0001012015,0.0000325472,0.0001997198,0.00002043913,0.0006970736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01550379,"threshold_uncertainty_score":0.8950297,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01332399475777889,"score_gpt":0.2333141324997061,"score_spread":0.2199901377419272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}