{"id":"W2783529487","doi":"10.1080/15592294.2018.1549769","title":"Genome-epigenome interactions associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome","year":2018,"lang":"en","type":"article","venue":"Epigenetics","topic":"Fibromyalgia and Chronic Fatigue Syndrome Research","field":"Medicine","cited_by":43,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Epigenetics; Biology; DNA methylation; Chronic fatigue syndrome; Genetics; CpG site; Epigenome; Single-nucleotide polymorphism; Genome-wide association study; Phenotype; Disease; Immune system; Encephalomyelitis; Genotype; Gene; Immunology; Multiple sclerosis; Gene expression; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0002729398,0.0003591226,0.0005282959,0.0002907861,0.0003444999,0.00006428692,0.0003023437,0.0001828425,0.004341768],"category_scores_gemma":[0.0001563417,0.0003072608,0.0001464049,0.0008180985,0.0006856975,0.0001113061,0.0001150155,0.0005468209,0.0008748794],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009104345,"about_ca_system_score_gemma":0.0009964952,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006020337,"about_ca_topic_score_gemma":0.00006956499,"domain_scores_codex":[0.9970683,0.0001225659,0.000481765,0.0005996508,0.0007407268,0.0009869329],"domain_scores_gemma":[0.997978,0.0001451383,0.0001523694,0.0007885383,0.0004825422,0.0004533892],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002270996,0.009184561,0.3155245,0.01255293,0.01604955,0.01607647,0.01971269,0.001410886,0.5539293,0.004995498,0.009366363,0.03892634],"study_design_scores_gemma":[0.003676159,0.01143324,0.9621894,0.001905941,0.0003553979,0.001476871,0.0003851736,0.0009276498,0.003868377,0.000343659,0.01252175,0.0009163513],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.98432,0.001880007,0.002055632,0.000706145,0.0002994508,0.0008038727,0.00004741671,0.0002034828,0.00968396],"genre_scores_gemma":[0.989249,0.0002554547,0.00110529,0.00002512298,0.0002014111,0.00006558764,0.0002117771,0.0000955272,0.008790867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.646665,"threshold_uncertainty_score":0.999938,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0337333156697553,"score_gpt":0.3070755651720306,"score_spread":0.2733422495022753,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}