{"id":"W2783535000","doi":"10.1038/nature25190","title":"Architecture of a channel-forming O-antigen polysaccharide ABC transporter","year":2018,"lang":"en","type":"article","venue":"Nature","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":98,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"National Institute of Biomedical Imaging and Bioengineering; National Center for Research Resources; National Institute of General Medical Sciences","keywords":"Periplasmic space; ATP-binding cassette transporter; Biochemistry; Transmembrane domain; Bacterial outer membrane; Aquifex aeolicus; Transporter; Inner membrane; Secretion; Cell biology; Biology; Transmembrane protein; Cyclic nucleotide-binding domain; Escherichia coli; Chemistry; Nucleotide; Amino acid; Membrane; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008912443,0.0002049573,0.0003571876,0.0001798707,0.0006077095,0.000964582,0.0005185975,0.0008349324,0.001329483],"category_scores_gemma":[0.0001265622,0.0002818386,0.000246772,0.0002138588,0.0004426478,0.0007768021,0.0002826492,0.0005588434,0.0009116799],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005833969,"about_ca_system_score_gemma":0.000523568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007500441,"about_ca_topic_score_gemma":0.0006053085,"domain_scores_codex":[0.9999585,0.00000612541,0.000002898629,0.00001137343,0.000009496744,0.00001156049],"domain_scores_gemma":[0.9999295,0.00000739758,0.00001005659,0.000007400797,0.000010505,0.00003520532],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000277131,0.0001105238,0.001158097,0.0001903099,0.00001839788,0.0007528264,0.0001532274,0.010126,0.9016781,0.07217748,0.002314445,0.01104344],"study_design_scores_gemma":[0.0001512854,0.001394181,0.01164102,0.00009992855,0.0001054257,0.002985722,0.0006037594,0.3657476,0.5081744,0.05419293,0.05473156,0.000172325],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9280007,0.001990215,0.04936446,0.002339892,0.0002126801,0.00006099265,0.0003603596,0.001130221,0.01654026],"genre_scores_gemma":[0.9796219,0.001181246,0.01336068,0.0002597132,0.00005315738,0.00003032285,0.0002720167,0.00004200863,0.005179063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001329483,"threshold_uncertainty_score":0.004447579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005161164183892847,"score_gpt":0.2469029822143232,"score_spread":0.2417418180304303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}