{"id":"W2783562181","doi":"10.1038/s41467-018-02863-3","title":"BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1","year":2018,"lang":"en","type":"article","venue":"Nature Communications","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":89,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver General Hospital; University of British Columbia","funders":"Houston Methodist Research Institute; Strong; University of Texas MD Anderson Cancer Center; Cancer Prevention and Research Institute of Texas; Fred Hutchinson Cancer Research Center; National Cancer Institute; National Institutes of Health; Prostate Cancer Foundation; National Heart, Lung, and Blood Institute; U.S. Department of Defense","keywords":"BMI1; Prostate cancer; Cancer research; Androgen receptor; Enzalutamide; Cancer stem cell; Biology; Mdm2; Histone; Transcription factor; Cancer; Epigenetics; Stem cell; Cell biology; Cell culture; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001679507,0.00009649844,0.0001869663,0.00009667414,0.0001808963,0.00001099053,0.0006187389,0.0001366588,0.0001459006],"category_scores_gemma":[0.0001280494,0.00006064934,0.00006614213,0.0005523036,0.0005749342,0.00005716459,0.0004027316,0.0006701834,0.000008936767],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001533278,"about_ca_system_score_gemma":0.0002778229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003239332,"about_ca_topic_score_gemma":0.001498479,"domain_scores_codex":[0.9990483,0.0001357816,0.0002218351,0.0001652212,0.0002461275,0.0001827559],"domain_scores_gemma":[0.9977216,0.00009727414,0.0001221555,0.001614127,0.0003898236,0.00005507625],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0007042697,0.0006300103,0.8959228,0.00007303683,0.0002855601,0.000003300356,0.004654101,0.000002482104,0.06426889,0.00209787,0.02428691,0.007070811],"study_design_scores_gemma":[0.003248292,0.0001922205,0.7744633,0.000569745,0.00009201233,0.00001658754,0.0004732009,0.0002279616,0.1266981,0.000593773,0.09325548,0.0001693927],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.911361,0.02802179,5.050811e-7,0.04691079,0.0002284587,0.001673966,0.0002690763,0.00004440725,0.01149006],"genre_scores_gemma":[0.9945247,0.002368839,0.0004949486,0.0002935639,0.00005219269,0.0001161563,0.00009388882,0.00001476072,0.002040965],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1214595,"threshold_uncertainty_score":0.2911651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0426611873875686,"score_gpt":0.3812908964847689,"score_spread":0.3386297090972003,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}