{"id":"W2783639731","doi":"10.1161/circgen.117.001758","title":"ExomeChip-Wide Analysis of 95 626 Individuals Identifies 10 Novel Loci Associated With QT and JT Intervals","year":2018,"lang":"en","type":"review","venue":"Circulation Genomic and Precision Medicine","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Common Fund; FP7 Health; Institute of Genetics; National Center for Advancing Translational Sciences; National Institute of Neurological Disorders and Stroke; National Institute of Diabetes and Digestive and Kidney Diseases; National Human Genome Research Institute; Helmholtz Zentrum München; National Heart, Lung, and Blood Institute; National Institute on Minority Health and Health Disparities; European Commission; Erasmus Universitair Medisch Centrum Rotterdam; National Institutes of Health; Hjartavernd; Novo Nordisk Foundation Center for Basic Metabolic Research; Université de Genève; Medical Research Council; National Institute of General Medical Sciences; Nierstichting; Leids Universitair Medisch Centrum; Diabetes Fonds; Deutsches Zentrum für Herz-Kreislaufforschung; Netherlands Heart Institute; Universitair Medisch Centrum Groningen; CARIM School for Cardiovascular Diseases, Universiteit Maastricht; Siemens; National Institute of Mental Health; Horizon 2020 Framework Programme; Hrvatska Zaklada za Znanost; National Cancer Institute; Lundbeckfonden; Bundesministerium für Bildung und Forschung; Háskóli Íslands; NIH Office of the Director; Universiteit Leiden; University of Washington; Münchner Zentrum für Gesundheitswissenschaften; Erasmus Medisch Centrum; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; Rijksuniversiteit Groningen; University of Leicester; School of Medicine, Boston University; Broad Institute; Universiteit Maastricht; ZonMw; Johns Hopkins University; Massachusetts General Hospital; National Science Foundation; National Institute for Health and Care Research; Queen Mary University of London; Harvard University; University of Miami; Yale University; National Institute on Drug Abuse; Novo Nordisk; University of Pennsylvania","keywords":"QT interval; Repolarization; Sudden cardiac death; Internal medicine; Cardiology; Medicine; Long QT syndrome; Afterdepolarization; Electrophysiology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001596113,0.0006735476,0.0008263037,0.0008823074,0.0005399329,0.001019087,0.0005992459,0.0007062299,0.002432419],"category_scores_gemma":[0.003192066,0.0003638215,0.002049525,0.001905869,0.0003170865,0.0002046368,0.0006192656,0.0005886677,0.0002179362],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002752754,"about_ca_system_score_gemma":0.0002940906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003301904,"about_ca_topic_score_gemma":0.004497366,"domain_scores_codex":[0.9983601,0.0003110043,0.0001462724,0.0008203568,0.0002223267,0.0001399856],"domain_scores_gemma":[0.9979751,0.00122879,0.0003448322,0.0002342006,0.000115128,0.0001018742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001939326,0.00007961492,0.9448829,0.0003251383,0.01421089,0.001333295,0.0002696294,0.001692371,0.01115304,0.0003381027,0.001613004,0.02216264],"study_design_scores_gemma":[0.000204678,0.0001373654,0.9886073,0.00004533275,0.005725252,0.0007088057,0.00009472435,0.0008935313,0.001276108,0.0003544727,0.001930439,0.00002201891],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9849244,0.00438884,0.004368189,0.0002761664,0.00005560101,0.00002650372,0.005019404,0.00006424788,0.0008766453],"genre_scores_gemma":[0.9940218,0.0008991142,0.001592917,0.0001523427,0.00003551747,0.00004704394,0.002828854,0.00002269919,0.0003995968],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.003301904,"threshold_uncertainty_score":0.00844115,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04609087670676769,"score_gpt":0.3259243567701208,"score_spread":0.2798334800633531,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}