{"id":"W2783654188","doi":"10.1002/ana.25144","title":"Dysfunctional sarcomere contractility contributes to muscle weakness in <i>ACTA1</i>‐related nemaline myopathy (NEM3)","year":2018,"lang":"en","type":"article","venue":"Annals of Neurology","topic":"Cardiomyopathy and Myosin Studies","field":"Medicine","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Child Health and Human Development; Medical Research Council; National Institute of Arthritis and Musculoskeletal and Skin Diseases; National Institute of General Medical Sciences; Office of Science; Vetenskapsrådet; National Institutes of Health; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; National Health and Medical Research Council; Muscular Dystrophy Association; Argonne National Laboratory; Eunice Kennedy Shriver National Institute of Child Health and Human Development; U.S. Department of Energy","keywords":"Nemaline myopathy; Sarcomere; Weakness; Dysfunctional family; Muscle weakness; Contractility; Medicine; Myopathy; Cardiology; Physical medicine and rehabilitation; Internal medicine; Myocyte; Anatomy; Psychiatry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002417571,0.0005727392,0.0002429408,0.000301935,0.0003035821,0.0001735185,0.0002032585,0.0004523986,0.001239254],"category_scores_gemma":[0.000316426,0.0001801116,0.0002915735,0.000181623,0.0004777928,0.0001778424,0.0003495688,0.0002902643,0.0002462577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000195654,"about_ca_system_score_gemma":0.00008449823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002607231,"about_ca_topic_score_gemma":0.0003492604,"domain_scores_codex":[0.9999058,0.00001366771,0.00001405109,0.00003240388,0.00001858431,0.00001542587],"domain_scores_gemma":[0.9997917,0.00003482791,0.0001102174,0.00001291799,0.00001583186,0.0000345245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009168446,0.0001295304,0.1424864,0.0001993507,0.00008873289,0.007790167,0.0001745528,0.0003357313,0.8419598,0.000103197,0.0002167661,0.005598883],"study_design_scores_gemma":[0.00007494369,0.0006616391,0.8589421,0.00004776858,0.0001118041,0.03650964,0.0002004706,0.001587038,0.1007892,0.0002086619,0.0008508242,0.00001580854],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992378,0.0001900663,0.0003405868,0.00002292721,0.000002356063,0.000004097889,0.00003587248,0.00000834999,0.0001579776],"genre_scores_gemma":[0.9992417,0.0001060086,0.0004291033,0.00002923466,0.000004621393,0.000006014376,0.0000644013,0.000004855925,0.0001140433],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001239254,"threshold_uncertainty_score":0.004145682,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04132105459112893,"score_gpt":0.3368069989571016,"score_spread":0.2954859443659727,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}