{"id":"W2783679151","doi":"10.1186/s12977-018-0388-3","title":"The HIV-1 accessory proteins Nef and Vpu downregulate total and cell surface CD28 in CD4+ T cells","year":2018,"lang":"en","type":"article","venue":"Retrovirology","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Western University; National Institutes of Health; Ministry of Training, Colleges and Universities","keywords":"Downregulation and upregulation; CD28; Cell biology; Biology; Cell; Immune system; T cell; Immunology; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003079743,0.0001661947,0.0002324519,0.00006300927,0.0003097166,0.00002850779,0.000154645,0.0002614819,0.0001931798],"category_scores_gemma":[0.00003123157,0.0001114202,0.00002919232,0.00008949292,0.00110622,0.00006444485,0.0002189822,0.0003235721,0.0009994406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003169299,"about_ca_system_score_gemma":0.00004968403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001874938,"about_ca_topic_score_gemma":0.000265293,"domain_scores_codex":[0.9984615,0.0003541018,0.0001918369,0.0003615603,0.00003301712,0.0005979346],"domain_scores_gemma":[0.9993419,0.0002406776,0.00006022798,0.0002773744,0.00003089854,0.00004890519],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0008382334,0.0001661994,0.05390821,0.00002263931,0.0001057596,0.00005107913,0.0005862653,0.000003832311,0.9352767,0.0002507341,0.002884295,0.00590603],"study_design_scores_gemma":[0.008968472,0.004626935,0.5707447,0.00002291446,0.00006016462,0.0003436756,0.0003335376,0.0000671201,0.3159518,0.0004960074,0.09786253,0.0005221087],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9924041,0.004308167,0.0000147547,0.001048444,0.0001605668,0.0004226237,0.00005416737,0.00002434062,0.001562843],"genre_scores_gemma":[0.992251,0.0005437459,0.00006609818,0.00006975028,0.00003193619,0.00002437882,0.00002953538,0.00001285888,0.006970682],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6193249,"threshold_uncertainty_score":0.9997784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006937492093092367,"score_gpt":0.2268730052422801,"score_spread":0.2199355131491878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}