{"id":"W2783684076","doi":"10.1016/j.jinsphys.2018.01.002","title":"DmCatD, a cathepsin D-like peptidase of the hematophagous insect Dipetalogaster maxima (Hemiptera: Reduviidae): Purification, bioinformatic analyses and the significance of its interaction with lipophorin in the internalization by developing oocytes","year":2018,"lang":"en","type":"article","venue":"Journal of Insect Physiology","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Fondo para la Investigación Científica y Tecnológica; National Institute of General Medical Sciences; Agencia Nacional de Promoción Científica y Tecnológica; Consejo Nacional de Investigaciones Científicas y Técnicas; Universidade Federal do Rio Grande do Sul; Universidad Nacional de Córdoba","keywords":"Biology; Biochemistry; Vitellogenesis; Yolk; Reduviidae; Cathepsin D; Immunoprecipitation; Internalization; Insect; Proteolysis; Cell biology; Hemolymph; Oocyte; Enzyme; Hemiptera; Gene; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007517513,0.0002433704,0.0002195999,0.0002854709,0.0001723346,0.0003319913,0.0001295564,0.0001878071,0.0005100304],"category_scores_gemma":[0.0001373,0.0001003926,0.0002669603,0.000219621,0.0001529004,0.0001955246,0.0001162397,0.0002884959,0.0002631299],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004707614,"about_ca_system_score_gemma":0.0002154281,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001312898,"about_ca_topic_score_gemma":0.001527629,"domain_scores_codex":[0.9999355,0.000005268713,0.000007009315,0.00002364749,0.00001590451,0.0000126479],"domain_scores_gemma":[0.9999393,0.00001385094,0.0000121842,0.000006086802,0.000009945908,0.00001870017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000139728,0.000007497165,0.001719569,0.00007012705,0.00001013214,0.0001015126,0.00001355983,0.00004637105,0.995539,0.0000515766,0.0000664533,0.002234457],"study_design_scores_gemma":[0.0000190153,0.0001080943,0.03825265,0.000007462708,0.00003776891,0.001418075,0.00007304836,0.001691455,0.9506131,0.00007033996,0.007698798,0.00001032013],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9868,0.002832157,0.006089016,0.0001411125,0.00003666222,0.00004286461,0.002951674,0.00007829969,0.001028238],"genre_scores_gemma":[0.9718403,0.001222463,0.01067237,0.0001112459,0.00001297824,0.00002513448,0.01298385,0.00003909856,0.003092399],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001312898,"threshold_uncertainty_score":0.003415585,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01821853612741392,"score_gpt":0.2692055445889411,"score_spread":0.2509870084615272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}