{"id":"W2783684076","doi":"10.1016/j.jinsphys.2018.01.002","title":"DmCatD, a cathepsin D-like peptidase of the hematophagous insect Dipetalogaster maxima (Hemiptera: Reduviidae): Purification, bioinformatic analyses and the significance of its interaction with lipophorin in the internalization by developing oocytes","year":2018,"lang":"en","type":"article","venue":"Journal of Insect Physiology","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"Fondo para la Investigación Científica y Tecnológica; National Institute of General Medical Sciences; Agencia Nacional de Promoción Científica y Tecnológica; Consejo Nacional de Investigaciones Científicas y Técnicas; Universidade Federal do Rio Grande do Sul; Universidad Nacional de Córdoba","keywords":"Biology; Biochemistry; Vitellogenesis; Yolk; Reduviidae; Cathepsin D; Immunoprecipitation; Internalization; Insect; Proteolysis; Cell biology; Hemolymph; Oocyte; Enzyme; Hemiptera; Gene; Embryo","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000375414,0.0001375605,0.0002643085,0.00007454247,0.00007162407,0.00001768216,0.0003558671,0.00007225176,0.000004057232],"category_scores_gemma":[0.0001159112,0.00006493925,0.00008810949,0.0002325337,0.0003558041,0.00002064837,0.00005271067,0.00014257,5.091059e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002055338,"about_ca_system_score_gemma":0.0001164457,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004527632,"about_ca_topic_score_gemma":0.0001403836,"domain_scores_codex":[0.9987627,0.0002587222,0.0005749047,0.0001221792,0.0001521463,0.0001293673],"domain_scores_gemma":[0.9983864,0.00007997184,0.0008950424,0.0002643761,0.0003574596,0.00001673341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001187771,0.00005853181,0.0008577835,0.00009402344,0.0001040637,7.354524e-7,0.002128622,0.00006379612,0.9949203,0.00005767703,0.0002409012,0.0002858517],"study_design_scores_gemma":[0.001128014,0.0006807544,0.02170434,0.0001914253,0.0000561225,0.0001816097,0.0007984588,0.0001151671,0.9742767,0.0001687604,0.000598713,0.00009994091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972866,0.001163559,0.0009588146,0.0002027722,0.0001009745,0.000218967,0.000005188518,0.000001016992,0.00006214542],"genre_scores_gemma":[0.9987549,0.0005486908,0.0002473305,0.0003019675,0.00009799283,0.00001251159,0.000006999826,0.000008507822,0.00002116679],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02084656,"threshold_uncertainty_score":0.2648146,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01821853612741392,"score_gpt":0.2692055445889411,"score_spread":0.2509870084615272,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}