{"id":"W2783692764","doi":"10.1038/nature25193","title":"A Myc enhancer cluster regulates normal and leukaemic haematopoietic stem cell hierarchies","year":2018,"lang":"en","type":"article","venue":"Nature","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":358,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Deutsches Krebsforschungszentrum","keywords":"Haematopoiesis; Enhancer; Biology; Stem cell; Progenitor cell; Myeloid; Transcription factor; RUNX1; Cell biology; Cancer research; Enhancer RNAs; Molecular biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001471238,0.0001403575,0.0001784776,0.0004909645,0.000333791,0.0007048441,0.0003840227,0.0002064288,0.003127858],"category_scores_gemma":[0.0002435745,0.0002156708,0.00014193,0.0001591544,0.0003685412,0.0003816101,0.0006697187,0.0005885647,0.0005725613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007180003,"about_ca_system_score_gemma":0.0002009298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008157751,"about_ca_topic_score_gemma":0.00196651,"domain_scores_codex":[0.9997304,0.00002917132,0.00001156504,0.0000650592,0.00007514058,0.00008872894],"domain_scores_gemma":[0.9996753,0.00006126366,0.00003916775,0.00003547864,0.00005603237,0.0001327713],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001459012,0.00001455933,0.0007655424,0.000007505275,0.000002554321,0.0000283015,0.00004135325,0.00004242768,0.9954551,0.001775145,0.0001087571,0.001612836],"study_design_scores_gemma":[0.00006725445,0.0001577272,0.05722342,0.0000104589,0.00001854636,0.0004008716,0.0002194058,0.002831129,0.9262149,0.001350303,0.01149166,0.00001430625],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908909,0.0005771288,0.003208312,0.00009470938,0.00002396698,0.0000117925,0.0002700586,0.0001417439,0.0047814],"genre_scores_gemma":[0.992831,0.0001140035,0.001390466,0.0000592744,0.00001087038,0.00001235263,0.0005461002,0.00009947945,0.004936428],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003127858,"threshold_uncertainty_score":0.01046365,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007558521614313518,"score_gpt":0.2731394814598352,"score_spread":0.2655809598455217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}