{"id":"W2783711120","doi":"10.1016/j.cell.2017.12.031","title":"BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Immune responses and vaccinations","field":"Immunology and Microbiology","cited_by":1176,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto; McGill University; Centre Hospitalier Universitaire Sainte-Justine; Université de Montréal; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Biology; Myelopoiesis; Innate immune system; Haematopoiesis; Stem cell; Immunology; Reprogramming; Lymphopoiesis; Adoptive cell transfer; Immunity; Progenitor cell; Immune system; Myeloid; Macrophage; Cell biology; Bone marrow; Cell; T cell; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002916966,0.0002631141,0.0001978098,0.0002795356,0.00008937303,0.0002622816,0.0001707358,0.0003818949,0.00225123],"category_scores_gemma":[0.000228327,0.0001077181,0.0001517609,0.00009739771,0.000207664,0.0001571928,0.0002659616,0.0009449499,0.0005182521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001333955,"about_ca_system_score_gemma":0.0001882767,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001137999,"about_ca_topic_score_gemma":0.0003449793,"domain_scores_codex":[0.9998224,0.0000617698,0.00001016941,0.00001734828,0.00004541382,0.00004296558],"domain_scores_gemma":[0.9998703,0.000033275,0.00002945054,0.0000156048,0.00001236843,0.00003894131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001039942,0.0005405219,0.002623185,0.000179929,0.00002250558,0.0001514348,0.00007064309,0.0003772231,0.9489963,0.001023483,0.0008429795,0.04413189],"study_design_scores_gemma":[0.0003086554,0.003475155,0.02064564,0.0000945673,0.0001546801,0.0004275341,0.0001308868,0.00231504,0.9546759,0.000905426,0.01685585,0.00001071108],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9830723,0.006080048,0.003935483,0.001103981,0.000310396,0.00005832091,0.0002041467,0.0002573347,0.004977921],"genre_scores_gemma":[0.9937975,0.001310084,0.00136386,0.0003058505,0.0001327453,0.00002316719,0.0001355897,0.00002036311,0.002910958],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00225123,"threshold_uncertainty_score":0.007531166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01277836307743993,"score_gpt":0.2429175230060925,"score_spread":0.2301391599286526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}