{"id":"W2783750102","doi":"10.1002/adfm.201705668","title":"Two‐Step Targeted Hybrid Nanoconstructs Increase Brain Penetration and Efficacy of the Therapeutic Antibody Trastuzumab against Brain Metastasis of HER2‐Positive Breast Cancer","year":2018,"lang":"en","type":"article","venue":"Advanced Functional Materials","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; University of Toronto","keywords":"Trastuzumab; Brain metastasis; Breast cancer; Cancer research; Metastasis; Medicine; Cancer; Pharmacology; Materials science; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000694042,0.0003318808,0.0001594851,0.0001343858,0.00005546994,0.0001417662,0.0001446912,0.0002563183,0.0007354183],"category_scores_gemma":[0.00008563983,0.0001240505,0.0001349706,0.00005961829,0.00009681157,0.0001562761,0.000132407,0.0002363987,0.0002278492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003209142,"about_ca_system_score_gemma":0.0001376935,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008980467,"about_ca_topic_score_gemma":0.001437664,"domain_scores_codex":[0.999946,0.000006123232,0.000002673624,0.00001189791,0.0000158142,0.00001750419],"domain_scores_gemma":[0.9999628,0.000009111342,0.000009603398,0.000003071964,0.000006084682,0.000009317863],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004855582,0.00003116812,0.00003380455,0.00001422905,0.000003251307,0.00001709383,0.000006166566,0.0001005196,0.9985897,0.00002499936,0.00004304492,0.001087519],"study_design_scores_gemma":[0.00001781864,0.0003600353,0.0008817096,0.000002358773,0.00001026819,0.00006094121,0.000003424896,0.001356455,0.9965878,0.000009132724,0.0007067683,0.000003286082],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961745,0.0007841954,0.0019882,0.00004115784,0.00001802208,0.00002111409,0.00006468569,0.0001171721,0.0007908925],"genre_scores_gemma":[0.9943117,0.0003659387,0.002894663,0.00005142614,0.000007735221,0.00003051108,0.0001125001,0.00002143172,0.002204187],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008980467,"threshold_uncertainty_score":0.002460241,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01359963853902267,"score_gpt":0.3087773613759019,"score_spread":0.2951777228368793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}