{"id":"W2783783326","doi":"10.1534/genetics.118.301116","title":"Human Enhancers Harboring Specific Sequence Composition, Activity, and Genome Organization Are Linked to the Immune Response","year":2018,"lang":"en","type":"article","venue":"Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Agence Nationale de la Recherche","keywords":"Biology; Enhancer; Genetics; Genome; Immune system; Human genome; Sequence (biology); Computational biology; Gene; Composition (language); Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001745072,0.0001176162,0.00008657296,0.00002817252,0.0002986625,0.00006762418,0.0002057318,0.00009001081,0.00001265741],"category_scores_gemma":[0.00001715095,0.0001098748,0.00001964698,0.0001264778,0.0001036274,0.000002070028,0.0002115812,0.00006289094,0.00001810955],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003311226,"about_ca_system_score_gemma":0.00003475175,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004748621,"about_ca_topic_score_gemma":0.00003062723,"domain_scores_codex":[0.9992879,0.00005975327,0.0001356161,0.0002588569,0.00008866595,0.0001691976],"domain_scores_gemma":[0.9992764,0.000005781551,0.00008234206,0.0003945149,0.0001814429,0.00005953081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003236545,0.00001242408,0.0004597383,0.000004579143,0.00001381532,7.574245e-7,0.000169144,0.0003327944,0.9986865,0.0000187742,0.00006434329,0.0002047574],"study_design_scores_gemma":[0.0002322784,0.0003152951,0.3554182,0.00001248102,0.000013172,0.0000167155,0.00009052032,0.0001850672,0.6353865,0.00003409261,0.008069907,0.0002258014],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942418,0.0003143469,0.004606966,0.0004724207,0.0001112171,0.0001826859,0.00002457018,0.00001069161,0.00003534203],"genre_scores_gemma":[0.997498,0.0001864887,0.001626631,0.0001575097,0.0003390675,0.000005964616,0.00004042816,0.00002824265,0.0001176408],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3633,"threshold_uncertainty_score":0.4480563,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120301025258799,"score_gpt":0.2447539526707287,"score_spread":0.2327238501448488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}