{"id":"W2783783326","doi":"10.1534/genetics.118.301116","title":"Human Enhancers Harboring Specific Sequence Composition, Activity, and Genome Organization Are Linked to the Immune Response","year":2018,"lang":"en","type":"article","venue":"Genetics","topic":"Genomics and Chromatin Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute; University of British Columbia","funders":"Agence Nationale de la Recherche","keywords":"Biology; Enhancer; Genetics; Genome; Immune system; Human genome; Sequence (biology); Computational biology; Gene; Composition (language); Transcription factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000164772,0.0001531024,0.0001920388,0.0005287641,0.0001232491,0.0002040264,0.00009891824,0.0001935901,0.001422484],"category_scores_gemma":[0.0003729995,0.000157027,0.0001956428,0.0003018659,0.0001298737,0.00009511051,0.0001657855,0.0002422767,0.000318113],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001070757,"about_ca_system_score_gemma":0.00008702153,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005661273,"about_ca_topic_score_gemma":0.001017451,"domain_scores_codex":[0.9998959,0.00001371948,0.000005630019,0.00004420369,0.00001803569,0.00002256817],"domain_scores_gemma":[0.9997743,0.00009996129,0.00005104389,0.00002492435,0.00002491574,0.00002495393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006865729,0.00003196545,0.04072026,0.0001997671,0.00006320263,0.0003703126,0.0002175501,0.0002759557,0.9399599,0.0006677579,0.0001842389,0.01662256],"study_design_scores_gemma":[0.00002925206,0.0001399965,0.7951794,0.00004145219,0.0001367296,0.003209611,0.0001043773,0.001388276,0.1910165,0.001086813,0.007641485,0.00002617091],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9906142,0.001888206,0.004043673,0.00004750833,0.000008788142,0.000009782157,0.001448064,0.00007723508,0.001862528],"genre_scores_gemma":[0.9931228,0.000454407,0.002670726,0.00005579249,0.00001015038,0.00001191751,0.002359755,0.00002278119,0.001291609],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001422484,"threshold_uncertainty_score":0.004758716,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0120301025258799,"score_gpt":0.2447539526707287,"score_spread":0.2327238501448488,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}