{"id":"W2783823546","doi":"10.1021/acs.biochem.7b01219","title":"PokMT1 from the Polyketomycin Biosynthetic Machinery of <i>Streptomyces diastatochromogenes</i> Tü6028 Belongs to the Emerging Family of <i>C</i>-Methyltransferases That Act on CoA-Activated Aromatic Substrates","year":2018,"lang":"en","type":"article","venue":"Biochemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Scripps Research Institute; China Pharmaceutical University; China Scholarship Council; Deutsche Forschungsgemeinschaft","keywords":"Methyltransferase; Chemistry; Biology; Biochemistry; Gene; Methylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006817349,0.0005314514,0.0003733031,0.0002405951,0.0002632004,0.0004181837,0.0001299451,0.0002549695,0.0008416197],"category_scores_gemma":[0.0002006145,0.0001046381,0.000341659,0.0003389024,0.0001583039,0.0002056059,0.0002420779,0.0004413541,0.0008841268],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00039827,"about_ca_system_score_gemma":0.0003643456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008508859,"about_ca_topic_score_gemma":0.0006350662,"domain_scores_codex":[0.999911,0.000005319338,0.000007905182,0.00002974782,0.00002759598,0.00001843742],"domain_scores_gemma":[0.9999202,0.000009005513,0.00002564062,0.000006908066,0.000009476858,0.00002861941],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001934949,0.00003439527,0.002609455,0.0001058491,0.00000697806,0.0001912412,0.00004213015,0.0002259175,0.9849982,0.0002538838,0.0002291229,0.01110939],"study_design_scores_gemma":[0.00003108309,0.0003259915,0.04679982,0.00002247388,0.00005442459,0.001789122,0.00009633782,0.004462522,0.9216234,0.0003468537,0.02441849,0.00002953806],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9843655,0.001055092,0.008448397,0.0001442489,0.00005988685,0.00005125409,0.002860517,0.0007509983,0.0022642],"genre_scores_gemma":[0.9732193,0.0005359354,0.00850492,0.0001156238,0.00001968533,0.00005341035,0.01309718,0.0001442842,0.004309619],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008508859,"threshold_uncertainty_score":0.002889633,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01654512584771968,"score_gpt":0.2522831209729473,"score_spread":0.2357379951252276,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}