{"id":"W2783878334","doi":"10.1021/acs.biochem.7b01292","title":"Structural Insight into the Discrimination between 8-Oxoguanine Glycosidic Conformers by DNA Repair Enzymes: A Molecular Dynamics Study of Human Oxoguanine Glycosylase 1 and Formamidopyrimidine-DNA Glycosylase","year":2018,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Lethbridge","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"DNA glycosylase; Glycosidic bond; DNA; DNA repair; Enzyme; Chemistry; Biochemistry; MUTYH; Uracil-DNA glycosylase","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002571013,0.0006885172,0.0008042112,0.0003268194,0.001031775,0.0007347108,0.0009695224,0.001166742,0.002391078],"category_scores_gemma":[0.000462084,0.0005188185,0.0007774304,0.0003619154,0.0006771819,0.001022766,0.0004460096,0.0009381742,0.0002339638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001173652,"about_ca_system_score_gemma":0.001063351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.009260857,"about_ca_topic_score_gemma":0.007880277,"domain_scores_codex":[0.9999056,0.00001305971,0.000003625465,0.00001965171,0.0000213674,0.00003683185],"domain_scores_gemma":[0.9998215,0.00005427076,0.00002303683,0.00001419817,0.0000330501,0.00005409012],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"simulation_or_modeling","study_design_gemma":"simulation_or_modeling","study_design_scores_codex":[0.0009675785,0.001144755,0.01721997,0.0002910334,0.0004155909,0.001326475,0.0007205627,0.8773415,0.07854214,0.009916289,0.002866076,0.009247939],"study_design_scores_gemma":[0.0001483678,0.0002562828,0.003921426,0.00001878025,0.00005148437,0.0000453358,0.0001762493,0.9901639,0.003173044,0.001223381,0.0007915045,0.00003021649],"study_design_candidate":"simulation_or_modeling","study_design_consensus":"simulation_or_modeling","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927603,0.0003769726,0.002959963,0.0004057948,0.00002668565,0.00002861659,0.00027188,0.00008387077,0.003086004],"genre_scores_gemma":[0.9955875,0.0004517002,0.00246575,0.0001143643,0.00001142589,0.00006627324,0.0007271438,0.00004448187,0.0005313203],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009260857,"threshold_uncertainty_score":0.0184139,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008271345624136532,"score_gpt":0.254928049736784,"score_spread":0.2466567041126474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}