{"id":"W2783965340","doi":"10.1074/jbc.m117.817635","title":"TRPM2 channel–mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":125,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University; Izaak Walton Killam Health Centre","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Autophagy; TRPM2; Cell biology; Cancer; Cancer research; Function (biology); Mitochondrion; Signal transduction; Cell function; Cell survival; Apoptosis; Cell; Biology; Chemistry; Medicine; Internal medicine; Transient receptor potential channel; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002672895,0.0001294063,0.0002957508,0.000020445,0.00007066895,0.000009117641,0.00008688585,0.0001819075,0.0005501786],"category_scores_gemma":[0.0001183396,0.00007042383,0.0001260226,0.0001234976,0.0002058205,0.0000470674,0.00002298275,0.0002068166,0.000001229259],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005445126,"about_ca_system_score_gemma":0.0001053168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007984155,"about_ca_topic_score_gemma":6.898892e-7,"domain_scores_codex":[0.9990164,0.00006120393,0.0004060882,0.0001390415,0.0002144501,0.0001628055],"domain_scores_gemma":[0.9989508,0.0001199453,0.0004476261,0.0001091333,0.0002503128,0.000122217],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001265805,0.0001619082,0.001053305,0.0000442339,0.00008729118,0.000009389672,0.00008564063,0.000004819467,0.9960506,0.000003447356,0.00004543852,0.001188132],"study_design_scores_gemma":[0.001897519,0.001068102,0.02986817,0.00008807755,0.0001074014,0.00007268238,0.0001432348,0.0003185864,0.9653434,0.0008122575,0.0001944671,0.00008606246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962685,0.001756483,0.001216291,0.0001848376,0.0002690068,0.0001238509,0.00001188883,0.00001310074,0.0001561006],"genre_scores_gemma":[0.9976295,0.0001696734,0.00009840831,0.00008965015,0.00190893,0.000004136405,0.00001365414,0.000008285372,0.0000777146],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03070715,"threshold_uncertainty_score":0.6024069,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02036040193094529,"score_gpt":0.2538789699465395,"score_spread":0.2335185680155942,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}