{"id":"W2783973260","doi":"10.3390/cancers10010018","title":"mTOR Pathways in Cancer and Autophagy","year":2018,"lang":"en","type":"review","venue":"Cancers","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":301,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Autophagy; TOR signaling; PI3K/AKT/mTOR pathway; Regulator; Cell biology; Signal transduction; Biology; Programmed cell death; Cell growth; Cancer cell; Cancer; Mechanistic target of rapamycin; Cell fate determination; Cancer research; Transcription factor; Apoptosis; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001658215,0.0003893759,0.0007497006,0.00009045147,0.00004450593,0.00002635054,0.0003156251,0.0005079039,0.0000892262],"category_scores_gemma":[0.0000442376,0.000358611,0.0001810551,0.000168753,0.0001872049,0.000002906598,0.0001394869,0.0002236091,0.00001559402],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008930418,"about_ca_system_score_gemma":0.00244759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000273345,"about_ca_topic_score_gemma":0.0003259382,"domain_scores_codex":[0.9983326,0.00006265908,0.0003612288,0.0007339581,0.0001241485,0.0003854532],"domain_scores_gemma":[0.9991522,0.00001653544,0.0002134516,0.0004473731,0.00005099607,0.0001194118],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002464257,0.00000905292,0.00002288919,0.005406932,0.0002265092,0.0000182792,0.00006234716,0.00002071165,0.000575956,0.00002882685,0.02001727,0.9735866],"study_design_scores_gemma":[0.000231037,0.0001141692,0.000004103265,0.003140979,0.0001112063,0.00001078002,0.00000586492,0.000007243905,0.0005327262,0.00001148557,0.9954222,0.0004081673],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0009705832,0.9965886,0.00001054638,0.000006393217,0.001104244,0.0003739922,0.0002170499,0.00001566617,0.0007128512],"genre_scores_gemma":[0.0001849563,0.996727,0.00009906094,0.0001672539,0.001419783,0.000432879,0.0001056407,0.00008295992,0.0007804057],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.975405,"threshold_uncertainty_score":0.9998866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04938152228318107,"score_gpt":0.3395178985096428,"score_spread":0.2901363762264618,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}