{"id":"W2783991301","doi":"10.1039/c7sc04491g","title":"A densely modified M<sup>2+</sup>-independent DNAzyme that cleaves RNA efficiently with multiple catalytic turnover","year":2018,"lang":"en","type":"article","venue":"Chemical Science","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Vancouver Biotech (Canada); University of British Columbia; University of British Columbia Hospital","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Deoxyribozyme; RNA; Catalysis; Chemistry; Ribozyme; Biochemistry; DNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001646795,0.0005027364,0.0002764144,0.0001247085,0.0001216982,0.0004548526,0.000592932,0.0007601167,0.001323283],"category_scores_gemma":[0.0003198451,0.0002730221,0.0001936732,0.000148348,0.0003145186,0.000269064,0.0003200669,0.000553251,0.001087709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002421446,"about_ca_system_score_gemma":0.000176311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001953699,"about_ca_topic_score_gemma":0.0004452685,"domain_scores_codex":[0.9998422,0.00002045591,0.00001088483,0.00005828001,0.00004472031,0.00002357267],"domain_scores_gemma":[0.9997721,0.00003003807,0.00006964758,0.00004032062,0.00002483707,0.000063076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004031958,0.000009598803,0.00006919983,0.00002480007,0.000003329727,0.00002614678,0.000004552573,0.00004633105,0.9979004,0.0001098907,0.00004817501,0.001717221],"study_design_scores_gemma":[0.00001062911,0.0001546771,0.0004494878,0.000002076375,0.000006856713,0.0003439267,0.000004320262,0.0003924896,0.9952937,0.00003686792,0.003299315,0.00000567189],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.885332,0.001921279,0.1021016,0.0003660853,0.0002621621,0.0001889623,0.0004487981,0.001265568,0.008113495],"genre_scores_gemma":[0.9121582,0.0005144773,0.07618584,0.0002634211,0.00005336028,0.00009957915,0.0006059122,0.0001785503,0.009940576],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001323283,"threshold_uncertainty_score":0.004426837,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01205216950485493,"score_gpt":0.2533481682126564,"score_spread":0.2412959987078014,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}