{"id":"W2784010067","doi":"10.1128/aem.02475-17","title":"Targeted Synthesis and Characterization of a Gene Cluster Encoding NAD(P)H-Dependent 3α-, 3β-, and 12α-Hydroxysteroid Dehydrogenases from Eggerthella CAG:298, a Gut Metagenomic Sequence","year":2018,"lang":"en","type":"article","venue":"Applied and Environmental Microbiology","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Hatch; University of Illinois at Urbana-Champaign","keywords":"Hydroxysteroid Dehydrogenases; Biology; Escherichia coli; Bile acid; Gene; Biochemistry; Hydroxysteroid; Metagenomics; Reductase; Enzyme; Farnesoid X receptor; Dehydrogenase; Transcription factor; Nuclear receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001506149,0.0005813834,0.0005184598,0.0004060891,0.0001847629,0.0003684147,0.0002458498,0.0003289146,0.0005394164],"category_scores_gemma":[0.0002495366,0.0001837529,0.0005126196,0.0005373212,0.0001880723,0.0001813882,0.0002649609,0.0004386519,0.0005724505],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002729685,"about_ca_system_score_gemma":0.0003196415,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001955845,"about_ca_topic_score_gemma":0.001579068,"domain_scores_codex":[0.9998562,0.000009960724,0.00001610488,0.00004755672,0.00004275962,0.0000272937],"domain_scores_gemma":[0.9997684,0.00005653676,0.00005801028,0.00002761021,0.00004413475,0.00004532332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004570679,0.00001738154,0.0002589014,0.0000291368,0.000003202269,0.00004591641,0.00001844598,0.00003126629,0.998733,0.00001850661,0.00001209134,0.0007864112],"study_design_scores_gemma":[0.00006646093,0.0005926954,0.05155789,0.00002776349,0.0001159612,0.0007396106,0.0003274049,0.002612055,0.9380955,0.0001404496,0.005702107,0.00002226719],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883967,0.0006225677,0.005121076,0.0001259644,0.0000355433,0.000124453,0.004732507,0.00005925599,0.0007819397],"genre_scores_gemma":[0.9590877,0.0008852587,0.01473878,0.00009847311,0.00003231142,0.0001234557,0.02097765,0.0001117727,0.003944484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001955845,"threshold_uncertainty_score":0.003888965,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007221349504306781,"score_gpt":0.1846033759931577,"score_spread":0.1773820264888509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}