{"id":"W2784017381","doi":"10.1039/c7md00569e","title":"Design, synthesis and evaluation of indole derivatives as multifunctional agents against Alzheimer's disease","year":2018,"lang":"en","type":"article","venue":"MedChemComm","topic":"Cholinesterase and Neurodegenerative Diseases","field":"Medicine","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Bell (Canada)","funders":"Division of Chemistry; Ministry of Education, India; University of the Western Cape; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Ministry of Earth Sciences; National Research Foundation","keywords":"Indole test; Neuroprotection; Combinatorial chemistry; Disease; Chemistry; Pharmacology; Medicine; Stereochemistry; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001753949,0.000246965,0.0001569699,0.0001697887,0.0001561318,0.0001620857,0.0003283807,0.0002155162,0.001265705],"category_scores_gemma":[0.00008560341,0.00009103509,0.0001533951,0.0001232163,0.00009086909,0.000158128,0.0001259852,0.0002310167,0.0002948241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000249446,"about_ca_system_score_gemma":0.0002132664,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00061412,"about_ca_topic_score_gemma":0.001615108,"domain_scores_codex":[0.9999642,0.000007369444,0.000003121803,0.000005365093,0.000006358998,0.00001360979],"domain_scores_gemma":[0.999971,0.000002890056,0.000007687861,0.000002585769,0.000007035227,0.00000880596],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005436498,0.0002337571,0.0001430059,0.0002332396,0.00001492718,0.0002210259,0.00006573437,0.001212178,0.9720808,0.0009880573,0.0004899229,0.02377377],"study_design_scores_gemma":[0.0001672868,0.003465054,0.001003649,0.00003518175,0.00004882068,0.0002620833,0.00003194035,0.00183,0.9726465,0.0001518204,0.02033861,0.00001906038],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9562267,0.01616417,0.01501079,0.0003289269,0.00009578246,0.0004540672,0.0006601553,0.0001912095,0.01086823],"genre_scores_gemma":[0.9783623,0.006274797,0.00923628,0.00009497235,0.00001724902,0.000130627,0.0004162032,0.00001408779,0.005453536],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001265705,"threshold_uncertainty_score":0.004234195,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1365036964631837,"score_gpt":0.3688422889049962,"score_spread":0.2323385924418124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}