{"id":"W2784034857","doi":"10.4049/jimmunol.1701212","title":"Staphylococcal Superantigens Use LAMA2 as a Coreceptor To Activate T Cells","year":2018,"lang":"en","type":"article","venue":"The Journal of Immunology","topic":"Immune Response and Inflammation","field":"Immunology and Microbiology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Lawson Health Research Institute; Western University; McGill University","funders":"Canadian Institutes of Health Research","keywords":"Superantigen; Cell biology; T-cell receptor; Toxic shock syndrome; Enterotoxin; T cell; G protein-coupled receptor; Tyrosine kinase; Receptor; Chemistry; Signal transduction; Biology; Immunology; Staphylococcus aureus; Biochemistry; Immune system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001301957,0.0004158189,0.0002061819,0.0001831178,0.0001586042,0.0003168324,0.0001646472,0.00031255,0.001390931],"category_scores_gemma":[0.00009237144,0.00009283406,0.0003453332,0.0001226964,0.0001112225,0.0002257334,0.0002624484,0.0004661355,0.0005897679],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000321378,"about_ca_system_score_gemma":0.0001680348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000517631,"about_ca_topic_score_gemma":0.0007572778,"domain_scores_codex":[0.999841,0.0000499245,0.00001020282,0.0000220974,0.00003139308,0.00004532591],"domain_scores_gemma":[0.9999577,0.000006821871,0.00001011852,0.000004570145,0.000008145991,0.00001273002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009066405,0.0000216546,0.0003685415,0.00003429153,0.00001093636,0.0001087021,0.000008037359,0.0000521055,0.9971089,0.00007044068,0.0001006523,0.002025054],"study_design_scores_gemma":[0.00004660715,0.0009692639,0.01263162,0.00001393037,0.00003950374,0.001149121,0.00007301095,0.002206166,0.9742146,0.00009892342,0.008547713,0.000009689453],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9805683,0.008419861,0.004757633,0.000425567,0.00006288504,0.000068453,0.0003067121,0.0001416106,0.005248996],"genre_scores_gemma":[0.9921398,0.001581149,0.002391415,0.0002483088,0.00003148642,0.00003483608,0.0003511233,0.000008994209,0.003213043],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001390931,"threshold_uncertainty_score":0.004653156,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01300011610303222,"score_gpt":0.2430676375839548,"score_spread":0.2300675214809226,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}