{"id":"W2784072336","doi":"10.1210/er.2017-00176","title":"The Extending Spectrum of NPC1-Related Human Disorders: From Niemann–Pick C1 Disease to Obesity","year":2018,"lang":"en","type":"review","venue":"Endocrine Reviews","topic":"Lysosomal Storage Disorders Research","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Impact","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; U.S. Department of Health and Human Services; National Institutes of Health; McMaster University; Servier; Société Francophone du Diabète","keywords":"NPC1; Niemann–Pick disease; Niemann–Pick disease, type C; Disease; Medicine; Neuroscience; Biology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003729353,0.0007221141,0.0009608709,0.002737808,0.0003196772,0.0008058728,0.0004763896,0.0007252207,0.004496949],"category_scores_gemma":[0.0006765098,0.0001739663,0.000470363,0.002072333,0.0003858184,0.0009010079,0.0006651797,0.001235875,0.002234289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000495815,"about_ca_system_score_gemma":0.001154455,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0010136,"about_ca_topic_score_gemma":0.001515728,"domain_scores_codex":[0.9998245,0.0000265444,0.00003968562,0.00003181721,0.00005817359,0.00001931115],"domain_scores_gemma":[0.9997543,0.00009380827,0.00004118086,0.000009318674,0.0000734587,0.00002800901],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009911003,0.00004461657,0.0004257441,0.01616913,0.0001058792,0.0006316231,0.0001211415,0.0001958391,0.002657331,0.003518467,0.03939703,0.9366341],"study_design_scores_gemma":[0.00001225225,0.00005743507,0.001129513,0.003169299,0.0001070593,0.005430531,0.00007457074,0.00004029729,0.0005853694,0.001841377,0.9875366,0.00001565221],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002078725,0.9972415,0.0001774484,0.0004268723,0.0002122623,0.000005126487,0.00003775867,0.00001556965,0.001675548],"genre_scores_gemma":[0.0009415692,0.9975854,0.0002681051,0.0002418358,0.0001643953,0.000006157193,0.00005962378,0.000002431391,0.000730491],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004496949,"threshold_uncertainty_score":0.01504385,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06694098546718064,"score_gpt":0.4114984650042574,"score_spread":0.3445574795370768,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}