{"id":"W2784162386","doi":"10.1021/acs.joc.7b02823","title":"Post Polyketide Synthase Carbon–Carbon Bond Formation in Type-II PKS-Derived Natural Products from <i>Streptomyces venezuelae</i>","year":2018,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Prince Edward Island; Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Streptomyces; Polyketide; Stereochemistry; Streptomycetaceae; Actinomycetales; Polyketide synthase; ATP synthase; Carbon fibers; Organic chemistry; Enzyme; Bacteria; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007778442,0.0002111702,0.000122601,0.0001298191,0.0001047203,0.0002828236,0.00009143897,0.00009188816,0.0004827758],"category_scores_gemma":[0.00007913834,0.00007098677,0.0001179717,0.0001858956,0.0001331378,0.0001469129,0.0001014685,0.0002531892,0.0001196796],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002123491,"about_ca_system_score_gemma":0.0002407652,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001258471,"about_ca_topic_score_gemma":0.002653429,"domain_scores_codex":[0.9999541,0.0000113002,0.0000040747,0.00001218878,0.000006852082,0.0000116138],"domain_scores_gemma":[0.9999559,0.000007312494,0.00001454621,0.000005655186,0.00000623314,0.00001035263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003812112,0.00002453751,0.0009793773,0.00005550583,0.000004687279,0.0001211954,0.00002857244,0.0001874748,0.9951863,0.0000941757,0.00001443211,0.002922569],"study_design_scores_gemma":[0.00002842879,0.000878969,0.01843351,0.00001375671,0.00003857733,0.000374418,0.000096631,0.0006503057,0.9768602,0.0001110624,0.002504342,0.000009856823],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966446,0.0007502433,0.0008448278,0.00001981116,0.000008977621,0.00001695523,0.0002819376,0.00001407803,0.001418408],"genre_scores_gemma":[0.9969358,0.0003566926,0.001450935,0.00001170702,0.00000255613,0.000007163364,0.0005290119,0.000005258702,0.0007008725],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001258471,"threshold_uncertainty_score":0.002502322,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006801249927471336,"score_gpt":0.2163986747875019,"score_spread":0.2095974248600306,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}