{"id":"W2784183730","doi":"10.1038/s41541-017-0043-3","title":"Humoral and cell-mediated immune responses to H5N1 plant-made virus-like particle vaccine are differentially impacted by alum and GLA-SE adjuvants in a Phase 2 clinical trial","year":2018,"lang":"en","type":"article","venue":"npj Vaccines","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":92,"is_retracted":false,"has_abstract":true,"ca_institutions":"Medicago (Canada); Caprion (Canada); McGill University Health Centre","funders":"Canadian Institutes of Health Research","keywords":"Alum; Immune system; Adjuvant; Virology; Virus-like particle; Biology; Immunology; Microbiology; Chemistry; Recombinant DNA; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001971926,0.0009716433,0.00133106,0.0002411222,0.0002698172,0.0006732399,0.0004485984,0.001044892,0.002242778],"category_scores_gemma":[0.0007012913,0.0003440101,0.0006488322,0.0002128433,0.0005797371,0.0005993219,0.0002124536,0.001988744,0.0004717121],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004069038,"about_ca_system_score_gemma":0.0007333708,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000221937,"about_ca_topic_score_gemma":0.0004977598,"domain_scores_codex":[0.9995134,0.000239916,0.00002924905,0.00006513056,0.00005612522,0.00009629079],"domain_scores_gemma":[0.9996189,0.00007968469,0.00008960798,0.00003119962,0.00004331196,0.0001373916],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5456604,0.1174216,0.003711853,0.0008338251,0.0005231702,0.0002163115,0.0003361237,0.001279943,0.257234,0.0002264271,0.001571216,0.07098514],"study_design_scores_gemma":[0.08831739,0.8891008,0.004967859,0.00002336984,0.0001582439,0.00009495871,0.00004010786,0.0004536379,0.01526188,0.0000822104,0.001485035,0.00001448679],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963192,0.0008137219,0.0003562274,0.0001549788,0.00007099338,0.001468175,0.0002646205,0.00003485288,0.0005172979],"genre_scores_gemma":[0.9925947,0.0008208593,0.001106435,0.0004210526,0.00009931445,0.001863556,0.0006753319,0.00001525102,0.002403525],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002242778,"threshold_uncertainty_score":0.01042867,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03056322054161581,"score_gpt":0.3404257586909937,"score_spread":0.3098625381493779,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}