{"id":"W2784294288","doi":"10.1002/btpr.2607","title":"Concomitant reduction of lactate and ammonia accumulation in fed‐batch cultures: Impact on glycoprotein production and quality","year":2018,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Polytechnique Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Wallonie-Bruxelles International","keywords":"Glutamine; Ammonia; Bioreactor; Cell culture; Fed-batch culture; Biochemistry; Chemistry; Metabolism; Food science; Biology; Fermentation; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005171127,0.0006707457,0.0007435657,0.0001757211,0.0002377357,0.0009417398,0.0004881362,0.0005411389,0.0005311109],"category_scores_gemma":[0.0003548358,0.0001788171,0.0004201519,0.0002779631,0.000216464,0.0003924965,0.0005041646,0.000881694,0.0003568949],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005790578,"about_ca_system_score_gemma":0.0004160604,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001676599,"about_ca_topic_score_gemma":0.002246404,"domain_scores_codex":[0.999617,0.00006343488,0.00004665749,0.00009596769,0.0001351891,0.00004170171],"domain_scores_gemma":[0.9997959,0.00003924025,0.00004588342,0.00002660908,0.00006356809,0.00002891114],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009433492,0.00003406801,0.0001847317,0.00004849083,0.00000609811,0.00003072825,0.00001256252,0.00006584565,0.9982111,0.00001736632,0.00005081742,0.001243848],"study_design_scores_gemma":[0.000006425105,0.0001679923,0.001267286,0.000008644844,0.00001620282,0.00006810548,0.00002394837,0.0008800565,0.9965005,0.00002193951,0.00102933,0.000009598749],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9827228,0.002696702,0.01071251,0.0003009102,0.0001683991,0.0001297116,0.001173722,0.0001581148,0.001937187],"genre_scores_gemma":[0.9641257,0.002373657,0.02559023,0.0002330272,0.00004212109,0.0002206985,0.002471587,0.0001237958,0.004819235],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001676599,"threshold_uncertainty_score":0.004201412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02203929376051215,"score_gpt":0.3537705551130303,"score_spread":0.3317312613525182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}