{"id":"W2784294288","doi":"10.1002/btpr.2607","title":"Concomitant reduction of lactate and ammonia accumulation in fed‐batch cultures: Impact on glycoprotein production and quality","year":2018,"lang":"en","type":"article","venue":"Biotechnology Progress","topic":"Viral Infectious Diseases and Gene Expression in Insects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"National Research Council Canada; Polytechnique Montréal","funders":"Fonds de recherche du Québec – Nature et technologies; Wallonie-Bruxelles International","keywords":"Glutamine; Ammonia; Bioreactor; Cell culture; Fed-batch culture; Biochemistry; Chemistry; Metabolism; Food science; Biology; Fermentation; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001825059,0.0001388339,0.0001578775,0.00009376101,0.00008359849,0.00001471407,0.00006496158,0.0003541179,0.00000309292],"category_scores_gemma":[0.0001256925,0.0001098921,0.00003319528,0.0001335584,0.0005192441,0.000009323819,0.00007670724,0.0001025701,0.000001057254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000194377,"about_ca_system_score_gemma":0.00002486679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001172081,"about_ca_topic_score_gemma":0.0000948025,"domain_scores_codex":[0.9990792,0.00007999265,0.0002190986,0.0003881082,0.00007434656,0.0001593135],"domain_scores_gemma":[0.9994664,0.000004249888,0.0001609343,0.0002519724,0.00007770906,0.00003869142],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001117864,0.0001396013,0.03604186,0.00003871396,0.0000353611,8.075376e-7,0.0001103833,0.000005940427,0.9505019,0.0001752482,0.0002513244,0.01158101],"study_design_scores_gemma":[0.0005507622,0.001858335,0.05642289,0.00007200622,0.000009276304,0.00002300824,0.000104976,0.00003764088,0.939962,0.0003320168,0.0004754533,0.0001516841],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9979736,0.0009528225,0.00001950167,0.0004357363,0.0001781834,0.0003744768,0.00001181431,0.00003070804,0.00002315423],"genre_scores_gemma":[0.9992496,0.0002536855,0.0002520366,0.00001469556,0.0001236805,0.00003682284,0.0000181274,0.00001039541,0.00004096545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02038102,"threshold_uncertainty_score":0.4481268,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02203929376051215,"score_gpt":0.3537705551130303,"score_spread":0.3317312613525182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}