{"id":"W2784314865","doi":"10.1042/cs20171525","title":"Aldosterone, SGK1, and ion channels in the kidney","year":2018,"lang":"en","type":"review","venue":"Clinical Science","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; British Heart Foundation","keywords":"SGK1; Aldosterone; Epithelial sodium channel; Mineralocorticoid receptor; Endocrinology; Mineralocorticoid; Internal medicine; Hyperaldosteronism; Nephron; Chemistry; Ion channel; Kidney; Receptor; Cell biology; Biology; Glucocorticoid; Medicine; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003263981,0.0005060158,0.0007010194,0.001330267,0.0002801092,0.0006743608,0.000523372,0.0007502378,0.001988431],"category_scores_gemma":[0.0004455373,0.0001514095,0.0003163488,0.001112603,0.0003605706,0.0009428338,0.0004906107,0.001536034,0.001031905],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004218608,"about_ca_system_score_gemma":0.0009797646,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006593654,"about_ca_topic_score_gemma":0.00117608,"domain_scores_codex":[0.9998953,0.00001323435,0.0000177665,0.00002140014,0.00004043322,0.0000118319],"domain_scores_gemma":[0.9998481,0.00005783117,0.00002418349,0.000005159512,0.00004412535,0.00002056494],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009926147,0.00007032204,0.0004712816,0.01531156,0.00009337068,0.0004371078,0.00009883376,0.0003314837,0.003473439,0.005827168,0.03545885,0.9383274],"study_design_scores_gemma":[0.00001160408,0.00007719874,0.001285085,0.001686068,0.00009331379,0.002151079,0.00005703548,0.00007456614,0.0005620981,0.003113331,0.9908736,0.00001499316],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001796272,0.9983096,0.0001277929,0.0004256836,0.0002505851,0.000002359561,0.00001434371,0.000008783694,0.0006811502],"genre_scores_gemma":[0.001137702,0.9976268,0.0001337027,0.0002162765,0.0002578507,0.000003725479,0.00002836841,0.000001277397,0.0005943776],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001988431,"threshold_uncertainty_score":0.006651998,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08709238763984926,"score_gpt":0.4117218558171963,"score_spread":0.324629468177347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}