{"id":"W2784314865","doi":"10.1042/cs20171525","title":"Aldosterone, SGK1, and ion channels in the kidney","year":2018,"lang":"en","type":"review","venue":"Clinical Science","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":82,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Canadian Institutes of Health Research; British Heart Foundation","keywords":"SGK1; Aldosterone; Epithelial sodium channel; Mineralocorticoid receptor; Endocrinology; Mineralocorticoid; Internal medicine; Hyperaldosteronism; Nephron; Chemistry; Ion channel; Kidney; Receptor; Cell biology; Biology; Glucocorticoid; Medicine; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001953565,0.0001427191,0.0003183555,0.00004366921,0.00009677485,0.00004649855,0.000501677,0.0002575844,0.000006840096],"category_scores_gemma":[0.0002628049,0.00008382356,0.0001280809,0.0002736111,0.0008409825,0.000004757341,0.00008776067,0.0001469306,0.00001643602],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006737105,"about_ca_system_score_gemma":0.0002431239,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003365993,"about_ca_topic_score_gemma":0.000003900212,"domain_scores_codex":[0.9985728,0.0001083926,0.0004220037,0.0005070208,0.0001769195,0.0002128336],"domain_scores_gemma":[0.9993449,0.00003542097,0.000134633,0.0003300204,0.00004109514,0.0001139693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000214246,0.0001468957,0.0002542421,0.001333815,0.00002019211,0.00000795913,0.0001185203,6.804433e-7,0.00007738817,0.0001626144,0.00742135,0.9904349],"study_design_scores_gemma":[0.00009979808,0.0001611947,0.0002033671,0.0006625474,0.00002805776,0.00001065762,0.000008371,0.000009448402,0.00002212844,0.00005365066,0.9986178,0.0001230296],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.005211072,0.9922665,0.00006981409,0.0002240858,0.001313244,0.0004513215,0.000008556593,0.000005255538,0.0004501535],"genre_scores_gemma":[0.003838699,0.9944348,0.00003880302,0.0003455444,0.001038955,0.00002010162,0.00007598312,0.000008026839,0.0001991424],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9911964,"threshold_uncertainty_score":0.3418226,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08709238763984926,"score_gpt":0.4117218558171963,"score_spread":0.324629468177347,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}