{"id":"W2784401093","doi":"10.1016/j.cell.2017.12.032","title":"Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules","year":2018,"lang":"en","type":"article","venue":"Cell","topic":"Amyotrophic Lateral Sclerosis Research","field":"Medicine","cited_by":966,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; National Human Genome Research Institute; Fonds de Recherche du Québec - Santé; Target ALS; National Institutes of Health; ALS Association; Larry L. Hillblom Foundation; Alfred P. Sloan Foundation","keywords":"Neurodegeneration; Biology; Stress granule; Proteome; Cell biology; Amyotrophic lateral sclerosis; Context (archaeology); Drosophila melanogaster; Genetics; Disease; Messenger RNA; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003131507,0.000155239,0.0003426325,0.0002940684,0.0003155635,0.0006915004,0.0002162484,0.0004581111,0.001218656],"category_scores_gemma":[0.00054731,0.0001541032,0.0002123181,0.000189668,0.0003050574,0.0007374971,0.0006474985,0.0004410664,0.0003497571],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001979227,"about_ca_system_score_gemma":0.0001114535,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001117583,"about_ca_topic_score_gemma":0.0002999865,"domain_scores_codex":[0.9997115,0.00004719888,0.00002721079,0.0001084336,0.00004908956,0.00005663369],"domain_scores_gemma":[0.9995974,0.00008012442,0.0001013875,0.00005227781,0.00005225274,0.0001164982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001968365,0.00001043179,0.002949149,0.00003264239,0.00001602867,0.0001020764,0.00005890925,0.00009954128,0.9948246,0.0002849131,0.00006062698,0.001364196],"study_design_scores_gemma":[0.00004321826,0.0004592658,0.3709944,0.000045763,0.0001110622,0.003205414,0.0007192534,0.006399897,0.6098218,0.002721717,0.005411028,0.00006714292],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996847,0.001009987,0.001292374,0.00006809973,0.00001835526,0.000003826814,0.0001325455,0.00002512482,0.0006027738],"genre_scores_gemma":[0.9986579,0.0002535159,0.0005528406,0.00005002399,0.00001246517,0.000004375635,0.0001687449,0.00001673791,0.0002833833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001218656,"threshold_uncertainty_score":0.004076779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05785912527376928,"score_gpt":0.2849623383853701,"score_spread":0.2271032131116008,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}