{"id":"W2784429314","doi":"10.1371/journal.pmed.1002482","title":"Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study","year":2018,"lang":"en","type":"article","venue":"PLoS Medicine","topic":"Metabolomics and Mass Spectrometry Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":499,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"U.S. National Library of Medicine; National Institute of Biomedical Imaging and Bioengineering; Canadian Institutes of Health Research; National Institutes of Health; Eisai; Cognoptix; BioClinica; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; Northern California Institute for Research and Education; F. Hoffmann-La Roche; University of Southern California; Biogen; Eli Lilly and Company; Bristol-Myers Squibb; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Neuropathology; Medicine; Alzheimer's disease; Alzheimer's Disease Neuroimaging Initiative; Neuroimaging; Disease; Internal medicine; Biomarker; Metabolomics; Pathology; Dementia; Neurology; Oncology; Physiology; Bioinformatics; Biology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000399909,0.0004353452,0.0002737514,0.0006240949,0.0001940508,0.0003139332,0.000151757,0.0002929818,0.0003881517],"category_scores_gemma":[0.0003734957,0.0001567372,0.0001770055,0.0003034021,0.0001770114,0.0001964829,0.0003294396,0.0002968045,0.0001284311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002221135,"about_ca_system_score_gemma":0.0001879002,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001161621,"about_ca_topic_score_gemma":0.001974831,"domain_scores_codex":[0.9998838,0.00002217788,0.000006340254,0.00005307066,0.00002105257,0.00001351511],"domain_scores_gemma":[0.9997981,0.00002562319,0.00007502687,0.0000212272,0.0000445265,0.00003549048],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.005565908,0.0007712162,0.6801347,0.0001329998,0.0006166744,0.0003956203,0.000340261,0.0005929649,0.2804651,0.0001316916,0.0004713103,0.03038157],"study_design_scores_gemma":[0.00004932917,0.0008836258,0.9833322,0.000007648865,0.000156531,0.0005083679,0.00007321077,0.001061463,0.01337061,0.0001221236,0.0004242504,0.00001066314],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986553,0.0003464459,0.0005164084,0.00001914452,0.000002698406,0.00002149537,0.0002763978,0.00001252033,0.0001495594],"genre_scores_gemma":[0.9978817,0.0001744274,0.001222957,0.00004846456,0.000007445753,0.00002837958,0.0004264837,0.000003691332,0.0002063819],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001161621,"threshold_uncertainty_score":0.00230974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01346814717243022,"score_gpt":0.2856852330316198,"score_spread":0.2722170858591896,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}