{"id":"W2784640691","doi":"10.1074/jbc.ra117.001446","title":"A PH-like domain of the Rab12 guanine nucleotide exchange factor DENND3 binds actin and is required for autophagy","year":2018,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Center for Research Resources; National Institute of General Medical Sciences; Canadian Institutes of Health Research","keywords":"Pleckstrin homology domain; Guanine nucleotide exchange factor; GTPase; Cell biology; Rab; EGF-like domain; Autophagy; Biology; Actin; MDia1; Biochemistry; Actin cytoskeleton; Binding domain; Cytoskeleton; Binding site; Signal transduction","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006211426,0.0002231245,0.0001695106,0.00008511187,0.0002534532,0.0001368516,0.000135961,0.0001839124,0.001866692],"category_scores_gemma":[0.0001204766,0.0001128313,0.0002758216,0.00008278717,0.0001794167,0.0001254503,0.0002780583,0.000341488,0.0006320782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003721468,"about_ca_system_score_gemma":0.0002025066,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006360227,"about_ca_topic_score_gemma":0.0009189939,"domain_scores_codex":[0.9999379,0.000007492112,0.000003873181,0.00001579725,0.00002286547,0.00001211848],"domain_scores_gemma":[0.999923,0.0000137156,0.00001846967,0.00001009192,0.00000927262,0.00002542534],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001099997,0.00001230477,0.000631701,0.00002759244,0.000004564624,0.0001536738,0.000006005266,0.00009079929,0.9974637,0.0001215564,0.00008047625,0.001297611],"study_design_scores_gemma":[0.00003931963,0.00009711889,0.04103392,0.00001148827,0.00001505442,0.001954849,0.00004580703,0.002833736,0.9464007,0.0001750133,0.007382048,0.00001096594],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922255,0.0005410868,0.004448042,0.0001520992,0.00002983454,0.00001861052,0.0005564147,0.00009138673,0.001937147],"genre_scores_gemma":[0.9950309,0.0001617143,0.002113684,0.0000901124,0.000006654666,0.00001324403,0.001001097,0.00001625756,0.001566315],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001866692,"threshold_uncertainty_score":0.006244719,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02261917511110129,"score_gpt":0.2518523659980076,"score_spread":0.2292331908869064,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}