{"id":"W2784678115","doi":"10.1126/scitranslmed.aao1613","title":"Dimethyl fumarate potentiates oncolytic virotherapy through NF-κB inhibition","year":2018,"lang":"en","type":"article","venue":"Science Translational Medicine","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa","funders":"Canadian Institutes of Health Research; Terry Fox Research Institute; Canadian Cancer Society","keywords":"Oncolytic virus; Virotherapy; Cancer research; Virology; Medicine; Chemistry; Tumor cells","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009555033,0.0001416845,0.0001267229,0.000119349,0.0003349596,0.0000219986,0.0002641826,0.00005836202,0.0005574123],"category_scores_gemma":[0.00006868616,0.0001129567,0.00004304064,0.0006050153,0.002269413,0.00002738766,0.00002120011,0.00009345981,0.00006732972],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002267939,"about_ca_system_score_gemma":0.0003306843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000306096,"about_ca_topic_score_gemma":0.0001038195,"domain_scores_codex":[0.998169,0.00006534938,0.000224805,0.000457332,0.0007343164,0.0003492032],"domain_scores_gemma":[0.9992228,0.00002461899,0.0000545093,0.0002793109,0.0003045042,0.0001143059],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005212384,0.00003519498,0.0002351819,0.000004318457,0.00001399636,0.000001202004,0.0002792571,0.00003273155,0.9922625,0.00031765,0.0002891875,0.006007475],"study_design_scores_gemma":[0.001370178,0.003318861,0.001684572,0.00003463714,0.000008759014,0.00001036149,0.00005783535,0.0003817023,0.9840513,0.004275068,0.004646898,0.0001598107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.980599,0.0009412735,0.008394444,0.005389635,0.0002693837,0.0003090818,0.00001141221,0.00002108858,0.004064674],"genre_scores_gemma":[0.9962456,0.0001764176,0.0009866152,0.001284468,0.0008721742,0.00001851247,0.00005824926,0.00001616502,0.00034184],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01564655,"threshold_uncertainty_score":0.8361748,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03141410922294196,"score_gpt":0.3604707164747241,"score_spread":0.3290566072517821,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}