{"id":"W2784732900","doi":"10.1016/j.immuni.2018.01.006","title":"Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity","year":2018,"lang":"en","type":"article","venue":"Immunity","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":286,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University; Université de Montréal; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Public Health Agency of Canada; Faculty of Medicine, McGill University","keywords":"Biology; Glycan; CD8; T cell; Glycoprotein; Glycosylation; Cell biology; Interleukin 15; Antigen; Membrane glycoproteins; Immunology; Cytokine; Interleukin; Molecular biology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":["insufficient_payload"],"category_scores_codex":[0.0006642764,0.0002486406,0.0003216219,0.0001161754,0.0005927014,0.00002888783,0.000174557,0.000272613,0.001697099],"category_scores_gemma":[0.0002609541,0.0002400082,0.00009346109,0.000243722,0.0002093575,0.0001106301,0.0002132121,0.0004688569,0.001296525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000996326,"about_ca_system_score_gemma":0.0001215844,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004516197,"about_ca_topic_score_gemma":0.004693249,"domain_scores_codex":[0.9980571,0.0006942748,0.0002956691,0.0003914553,0.00003485365,0.0005265923],"domain_scores_gemma":[0.998998,0.0001613629,0.0001251136,0.0004482849,0.0001668972,0.0001003028],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004934869,0.0001287786,0.001284628,0.000009391694,0.00005716937,0.000001993692,0.0007833429,4.186636e-7,0.9738329,0.000008674476,0.007887031,0.01551219],"study_design_scores_gemma":[0.0006242736,0.000704264,0.007784732,0.00003866071,0.00002521624,0.00004329986,0.0002596194,0.000001828388,0.8944693,0.00002780026,0.09576,0.000260981],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903224,0.0007546085,0.00150926,0.0001164367,0.001450949,0.0002115901,0.00004839685,0.0001507524,0.005435567],"genre_scores_gemma":[0.9957374,0.00002251462,0.0000521483,0.001033531,0.0001290619,0.00001365998,0.0001393674,0.00002514437,0.002847138],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08787297,"threshold_uncertainty_score":0.9994811,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007001849584130599,"score_gpt":0.2294242903828355,"score_spread":0.2224224407987049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}