{"id":"W2784732900","doi":"10.1016/j.immuni.2018.01.006","title":"Interleukin-10 Directly Inhibits CD8+ T Cell Function by Enhancing N-Glycan Branching to Decrease Antigen Sensitivity","year":2018,"lang":"en","type":"article","venue":"Immunity","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":286,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal; McGill University; Université de Montréal; McGill University Health Centre","funders":"National Institute of Allergy and Infectious Diseases; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Fonds de Recherche du Québec - Santé; Public Health Agency of Canada; Faculty of Medicine, McGill University","keywords":"Biology; Glycan; CD8; T cell; Glycoprotein; Glycosylation; Cell biology; Interleukin 15; Antigen; Membrane glycoproteins; Immunology; Cytokine; Interleukin; Molecular biology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001435933,0.000390312,0.0001722073,0.0001299413,0.00007696306,0.0002446978,0.0002254903,0.000356814,0.003216096],"category_scores_gemma":[0.0001470656,0.0001341427,0.0002197023,0.00007735444,0.0002437327,0.0001487244,0.0001370156,0.001327051,0.0005522096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002501433,"about_ca_system_score_gemma":0.0002602467,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004355616,"about_ca_topic_score_gemma":0.00100373,"domain_scores_codex":[0.9998378,0.00004049691,0.00001039001,0.00001564409,0.00002886989,0.00006684293],"domain_scores_gemma":[0.9998672,0.00004075328,0.00002072782,0.00001422092,0.00001030751,0.00004683235],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005865235,0.000285635,0.0002737442,0.00005225067,0.000009295376,0.00004680983,0.000009591137,0.0001952853,0.9952642,0.0000985419,0.0002293835,0.002948812],"study_design_scores_gemma":[0.0001867939,0.001600349,0.002019963,0.000008200706,0.00001842616,0.0001044801,0.00001705419,0.001048635,0.9928883,0.00007004212,0.002033216,0.000004586307],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992285,0.001103896,0.001880115,0.0004641443,0.0001868322,0.00004091247,0.0001863731,0.0001453127,0.003707468],"genre_scores_gemma":[0.9943861,0.0007523251,0.001480504,0.0001960742,0.00003952913,0.00003822185,0.000189171,0.0000188222,0.002899411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003216096,"threshold_uncertainty_score":0.01075888,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007001849584130599,"score_gpt":0.2294242903828355,"score_spread":0.2224224407987049,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}