{"id":"W2784746802","doi":"10.1182/blood.v130.suppl_1.4076.4076","title":"A Single Direct Intratumoral Injection of TTI-621 (SIRPαFc) Induces Antitumor Activity in Patients with Relapsed/Refractory Mycosis Fungoides and Sézary Syndrome: Preliminary Findings Employing an Immune Checkpoint Inhibitor Blocking the CD47 Do Not Eat Signal","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Phagocytosis and Immune Regulation","field":"Immunology and Microbiology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"Trillium Therapeutics (Canada)","funders":"","keywords":"Medicine; Mycosis fungoides; Immune checkpoint; Tumor microenvironment; Internal medicine; Melanoma; Immune system; Cancer research; Cancer; Immunology; Oncology; Lymphoma; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004925602,0.0002821588,0.00048781,0.0001920083,0.0007119114,0.0001136663,0.0002792795,0.0002385989,0.00001537268],"category_scores_gemma":[0.0001130992,0.0002103758,0.00008027237,0.0001277018,0.0003845376,0.0009599373,0.0002210096,0.0004578465,0.000002234782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005619632,"about_ca_system_score_gemma":0.00005787113,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003470705,"about_ca_topic_score_gemma":0.00003851065,"domain_scores_codex":[0.9984116,0.0002746916,0.000429555,0.0004315971,0.0001056339,0.0003469474],"domain_scores_gemma":[0.9986863,0.0001252978,0.0005625198,0.0005118652,0.00008703002,0.00002697781],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009376517,0.001435262,0.2581204,0.00004735698,0.0001353368,0.000006140882,0.0008156713,0.000004547654,0.7343658,0.000004346588,0.000003819075,0.004123722],"study_design_scores_gemma":[0.002136449,0.001904654,0.5518163,0.0003022524,0.00008581058,0.00005129843,0.00010085,0.000003270323,0.4434345,0.000005934674,0.000006837509,0.0001518033],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9980204,0.001129486,0.00000217101,0.00004111505,0.000235129,0.0004490726,0.00002222452,0.0000373361,0.00006306016],"genre_scores_gemma":[0.9997686,0.00003636288,0.00003148803,0.00000792887,0.00002679746,0.00003145271,0.00003534117,0.00003132978,0.00003066011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2936959,"threshold_uncertainty_score":0.8578876,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01462004280637729,"score_gpt":0.2204256022449864,"score_spread":0.2058055594386091,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}