{"id":"W2784802611","doi":"10.1073/pnas.1715997115","title":"STAC proteins associate to the IQ domain of Ca <sub>V</sub> 1.2 and inhibit calcium-dependent inactivation","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":46,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Austrian Science Fund; RYR-1 Foundation","keywords":"Calcium; Gene isoform; Signal transducing adaptor protein; Calcium channel; Chemistry; Calcium-binding protein; Cell biology; Biology; Biochemistry; Signal transduction; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009883478,0.00005837954,0.00007015,0.00006541565,0.000164464,0.00001212457,0.0001951443,0.00007803603,0.000002497983],"category_scores_gemma":[0.0003133315,0.00003605547,0.00003131529,0.0002892022,0.0003649281,0.00002173133,0.0001096286,0.00005375817,6.823558e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000189339,"about_ca_system_score_gemma":0.00002796433,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005575117,"about_ca_topic_score_gemma":7.672809e-7,"domain_scores_codex":[0.9990364,0.000009744316,0.0001876618,0.0001598448,0.0005218626,0.00008444812],"domain_scores_gemma":[0.9992744,0.00001399751,0.0002809588,0.000009131884,0.000399754,0.00002174089],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003280192,0.00001683589,0.0007063518,0.00001152132,0.000008598887,4.33956e-10,0.000141341,0.00002946272,0.9951733,0.002631744,0.0006981815,0.000549891],"study_design_scores_gemma":[0.0001229757,0.0001383386,0.02192632,0.00002292735,0.000003874576,0.000001502047,0.0002038492,0.0001745985,0.973507,0.003253095,0.0006031279,0.00004233256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955097,0.00002200684,0.000065602,0.003256114,0.00003106311,0.0002312432,0.00001367389,0.000002260924,0.0008683532],"genre_scores_gemma":[0.9992865,0.000008240218,0.0002287449,0.0002164582,0.0001653709,0.00001190747,5.621839e-7,0.000002794512,0.00007946417],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02166622,"threshold_uncertainty_score":0.14703,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.025695026250907,"score_gpt":0.2824239798276447,"score_spread":0.2567289535767378,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}