{"id":"W2784833105","doi":"10.2174/1381612824666180125093357","title":"The Emerging Therapeutic Landscape of Advanced Melanoma","year":2018,"lang":"en","type":"review","venue":"Current Pharmaceutical Design","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Oncolytics Biotech; Amgen","keywords":"Medicine; Therapeutic modalities; Melanoma; Modalities; Intensive care medicine; Cancer; Immunotherapy; Treatment modality; Skin cancer; Metastatic melanoma; Internal medicine; Cancer research","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005961122,0.000428332,0.0007006006,0.000055646,0.0001565518,0.00003100089,0.000679624,0.0002359651,0.00005047265],"category_scores_gemma":[0.0001027137,0.0002664666,0.0004763966,0.0001694368,0.0002164168,0.000003205664,0.0001929326,0.0003168258,0.00007574542],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001448367,"about_ca_system_score_gemma":0.0002640973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":1.114957e-7,"about_ca_topic_score_gemma":1.880641e-7,"domain_scores_codex":[0.9976757,0.0005094722,0.0006094613,0.0005103091,0.0002274765,0.0004675919],"domain_scores_gemma":[0.9986408,0.0001925165,0.0003050791,0.0006006453,0.0001017454,0.0001591744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005761971,0.00005959854,0.000001981718,0.001995914,0.0001976869,0.000001568808,0.000007752579,7.515246e-7,0.000535337,0.0002632512,0.003831418,0.9930471],"study_design_scores_gemma":[0.0002984115,0.0002800618,9.570331e-7,0.0009626162,0.000480971,0.00001841487,0.000005711484,0.00004903637,0.002302363,0.00006018898,0.9952298,0.0003114694],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00001529998,0.9927241,0.004390362,0.00001221222,0.001451364,0.0008084971,0.00003567196,0.00001751096,0.0005450186],"genre_scores_gemma":[0.0002658369,0.9983214,0.0001490399,0.00002139235,0.0007070952,0.0001493963,0.0001273914,0.00005877791,0.0001997087],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9927356,"threshold_uncertainty_score":0.9999788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1213565207152266,"score_gpt":0.406393798695927,"score_spread":0.2850372779807004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}