{"id":"W2784833105","doi":"10.2174/1381612824666180125093357","title":"The Emerging Therapeutic Landscape of Advanced Melanoma","year":2018,"lang":"en","type":"review","venue":"Current Pharmaceutical Design","topic":"Melanoma and MAPK Pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Oncolytics Biotech; Amgen","keywords":"Medicine; Therapeutic modalities; Melanoma; Modalities; Intensive care medicine; Cancer; Immunotherapy; Treatment modality; Skin cancer; Metastatic melanoma; Internal medicine; Cancer research","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004740167,0.0005157971,0.000725483,0.001225409,0.0003061587,0.0009855311,0.0005021088,0.001045977,0.003477213],"category_scores_gemma":[0.0004538478,0.0001749462,0.0003554013,0.0007914101,0.0003988546,0.001384123,0.000662062,0.002034234,0.001380207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000466253,"about_ca_system_score_gemma":0.0007197319,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003918807,"about_ca_topic_score_gemma":0.0009595032,"domain_scores_codex":[0.9998527,0.00003113328,0.00001550839,0.00002304598,0.00005936768,0.00001830591],"domain_scores_gemma":[0.999851,0.00006049926,0.00001887269,0.000005120361,0.00004465949,0.0000197889],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007815642,0.00009481028,0.0001438587,0.01384241,0.00004820894,0.0004194803,0.0001095852,0.0003959386,0.006840776,0.01277982,0.03285626,0.9323907],"study_design_scores_gemma":[0.00001191044,0.00009564361,0.0003064612,0.00151442,0.00003122219,0.001217585,0.0000561629,0.0001039856,0.0007460427,0.003141851,0.9927644,0.00001022772],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002460809,0.9964049,0.0002637744,0.0008195557,0.0003381023,0.000005911105,0.00001751289,0.00001093952,0.001893182],"genre_scores_gemma":[0.001810471,0.9960548,0.0003357489,0.0004817186,0.0003115143,0.000009212468,0.00002844867,0.000002211431,0.0009657706],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003477213,"threshold_uncertainty_score":0.01163244,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1213565207152266,"score_gpt":0.406393798695927,"score_spread":0.2850372779807004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}