{"id":"W2784884331","doi":"10.1371/journal.pone.0191743","title":"Contribution of oxidative stress and growth factor receptor transactivation in natriuretic peptide receptor C-mediated attenuation of hyperproliferation of vascular smooth muscle cells from SHR","year":2018,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Heart Failure Treatment and Management","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Heart and Stroke Foundation of Canada","keywords":"Endocrinology; Internal medicine; NADPH oxidase; Angiotensin II; NOX4; Vascular smooth muscle; Chemistry; Receptor; Oxidative stress; Biology; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001392446,0.0004325107,0.0005328768,0.0002459583,0.0001868321,0.0001901122,0.0001390847,0.0002196139,0.001381947],"category_scores_gemma":[0.00009926246,0.0001907228,0.0003619294,0.00009416296,0.0002346727,0.0001826069,0.0002436021,0.0007180455,0.0001728716],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001500738,"about_ca_system_score_gemma":0.0002493706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009109531,"about_ca_topic_score_gemma":0.001254706,"domain_scores_codex":[0.9999025,0.00001701315,0.000009248699,0.00001877006,0.00001952969,0.00003284341],"domain_scores_gemma":[0.999884,0.000008034579,0.00002952608,0.00001061425,0.00001402685,0.00005368458],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000587112,0.00006992943,0.0003068839,0.00005359907,0.0000121837,0.00009730228,0.00002202861,0.00002298447,0.9973608,0.00003499299,0.00002081178,0.001411576],"study_design_scores_gemma":[0.0001982136,0.003941205,0.06544682,0.00002787095,0.0001743434,0.0007375678,0.0002087911,0.001545568,0.9249326,0.0001740038,0.002591235,0.00002172139],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974931,0.00121486,0.0006015755,0.00007366663,0.00002292713,0.00002537367,0.0001021319,0.00002419141,0.0004421351],"genre_scores_gemma":[0.9953527,0.001658297,0.001027524,0.00008484611,0.00002435864,0.00005909655,0.0002217559,0.000009039856,0.001562294],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001381947,"threshold_uncertainty_score":0.004623055,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01859986238238609,"score_gpt":0.2219230814783437,"score_spread":0.2033232190959576,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}