{"id":"W2784916289","doi":"10.1136/gutjnl-2017-314426","title":"Cell of origin affects tumour development and phenotype in pancreatic ductal adenocarcinoma","year":2018,"lang":"en","type":"article","venue":"Gut","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":138,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; Canadian Institutes of Health Research; Pancreatic Cancer Canada Foundation","keywords":"Pancreatic Intraepithelial Neoplasia; Ductal cells; KRAS; Transdifferentiation; Acinar cell; Pathology; Biology; Cancer research; Phenotype; Metaplasia; Context (archaeology); Pancreatic duct; Pancreas; Pancreatic cancer; Adenocarcinoma; Cell; Cancer; Medicine; Mutation; Endocrinology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002610202,0.00008806387,0.0003397109,0.0001173678,0.00003281534,0.000003370852,0.00005098811,0.00006547644,0.0001525532],"category_scores_gemma":[0.00008595875,0.00007124706,0.00001578703,0.0001422163,0.000168875,0.00002480121,0.00004593082,0.0001081251,0.00009866762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000618398,"about_ca_system_score_gemma":0.0003354229,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009999282,"about_ca_topic_score_gemma":0.00004610507,"domain_scores_codex":[0.9992166,0.00004416868,0.0001749136,0.0001669349,0.0001665206,0.0002308681],"domain_scores_gemma":[0.9995735,0.00009605804,0.00004210525,0.000131452,0.00005404238,0.0001027996],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001461226,0.0001081162,0.9820583,0.0002123594,0.00002544358,0.00009065273,0.00134757,2.991836e-8,0.01492671,0.000143917,0.0004992989,0.0004414624],"study_design_scores_gemma":[0.001565555,0.0004784675,0.9901589,0.0001057739,0.00006282063,0.00004055222,0.0001988831,0.0001171238,0.006694011,0.00007147785,0.0004382712,0.00006814332],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9846033,0.0008241388,0.00003390023,0.0001215741,0.00004118947,0.0002735096,9.027449e-7,0.00001089222,0.01409057],"genre_scores_gemma":[0.9934737,0.00003500559,0.004763993,0.00005743374,0.00009384576,0.00001509213,0.000004204061,0.000009711459,0.001546975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01254359,"threshold_uncertainty_score":0.2905371,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03244355371584551,"score_gpt":0.315994149881824,"score_spread":0.2835505961659785,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}