{"id":"W2784962716","doi":"10.1016/j.celrep.2017.12.096","title":"The E3 Ubiquitin Ligase HectD1 Suppresses EMT and Metastasis by Targeting the +TIP ACF7 for Degradation","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Cancer Cells and Metastasis","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Institute for Research in Immunology and Cancer; Université de Montréal; Montreal Clinical Research Institute","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; Cancer Research Society","keywords":"Ubiquitin ligase; Metastasis; Epithelial–mesenchymal transition; Ubiquitin; Cancer research; Cisplatin; Chemistry; Cancer; Biology; Cell biology; Biochemistry; Chemotherapy; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000971275,0.0001527858,0.0002166453,0.00002579665,0.0004967344,0.00008379565,0.0000644942,0.0000484868,0.00008510979],"category_scores_gemma":[0.0004213927,0.00008371496,0.0001054024,0.0001148495,0.0002254027,0.00006679589,0.00005563175,0.0001033757,0.00000350745],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002908544,"about_ca_system_score_gemma":0.00009472566,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000138024,"about_ca_topic_score_gemma":0.00005667467,"domain_scores_codex":[0.9987112,0.00004409575,0.0003867564,0.0003253902,0.0002295947,0.0003029821],"domain_scores_gemma":[0.9987056,0.00028596,0.0002781773,0.0004295773,0.0001850647,0.0001156542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002844766,0.0001376633,0.001245187,0.0002891379,0.00017747,0.0001019322,0.0009674499,0.000001297205,0.2910667,0.00005690615,0.5839909,0.1216808],"study_design_scores_gemma":[0.0002235496,0.0001079981,0.0001191731,0.00001607583,0.0002037079,0.00009402411,0.0004589105,0.00001749145,0.5119146,0.0001014763,0.4866755,0.00006753135],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9733953,0.01444091,0.001307327,0.003625985,0.0008034444,0.001307328,0.00004242261,0.00006371123,0.005013574],"genre_scores_gemma":[0.9907904,0.0009704651,0.0010197,0.0004992417,0.0004961941,0.0001160823,0.00008086991,0.00003414155,0.005992962],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2208479,"threshold_uncertainty_score":0.382053,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01532622719109019,"score_gpt":0.2735800095616954,"score_spread":0.2582537823706053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}