{"id":"W2785043177","doi":"10.1038/nature25459","title":"Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes","year":2018,"lang":"en","type":"article","venue":"Nature","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":445,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Deutsche Forschungsgemeinschaft; Medical Research Council; Deutschen Konsortium für Translationale Krebsforschung; Helmholtz-Gemeinschaft; Partenariat Canadien Contre Le Cancer; Cancer Research UK","keywords":"KRAS; Biology; Carcinogenesis; Phenotype; Pancreatic cancer; Cancer research; Metastasis; Gene dosage; CDKN2A; Transcriptome; Cancer; Genetics; Gene; Mutation; Gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004349292,0.0004974453,0.0004188624,0.001441258,0.0004420794,0.001304014,0.0005412233,0.0009047333,0.002330582],"category_scores_gemma":[0.0006204989,0.0005864129,0.0003387877,0.0007077391,0.0007731863,0.0009511558,0.00142099,0.001296883,0.0007024583],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000442839,"about_ca_system_score_gemma":0.000259311,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002923423,"about_ca_topic_score_gemma":0.0007369828,"domain_scores_codex":[0.9996279,0.00007668593,0.00003595761,0.0000917688,0.0001062702,0.000061277],"domain_scores_gemma":[0.9994087,0.0001646998,0.0001843186,0.0000987895,0.00005845883,0.00008501095],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005566529,0.00004540711,0.01988673,0.00007041341,0.00004836808,0.001120129,0.0002675765,0.0009251992,0.9506406,0.007813523,0.0001792698,0.01844617],"study_design_scores_gemma":[0.00008769262,0.000574086,0.3777128,0.0001001355,0.0002220965,0.0152274,0.001150839,0.008923138,0.5477219,0.01442928,0.03367673,0.0001739053],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835272,0.0009550005,0.007267964,0.0003031199,0.0000309428,0.00002084693,0.0004783836,0.0001396043,0.007276921],"genre_scores_gemma":[0.9892802,0.001083161,0.004192516,0.0001603908,0.00002394487,0.00002484943,0.0004308911,0.0002800284,0.004524093],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002330582,"threshold_uncertainty_score":0.007796526,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004210390131888475,"score_gpt":0.2421230651129763,"score_spread":0.2379126749810878,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}