{"id":"W2785095220","doi":"10.1016/j.celrep.2017.12.083","title":"CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Simon Fraser University","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Merck Sharp and Dohme; Janssen Biotech; Canadian Institutes of Health Research; Innovative Medicines Initiative; Michael Smith Health Research BC; Wellcome Trust; Mount Sylvia Diatomite; Novartis Pharma; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Genome Canada; Boehringer Ingelheim; Pfizer UK; Merck KGaA; AbbVie; Takeda Pharmaceutical Company; Pfizer","keywords":"Kinase; Function (biology); Protein-Serine-Threonine Kinases; Cilium; Biology; Cell biology; Genetics; Computational biology; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005948238,0.000156477,0.0001102896,0.00002195985,0.0001300707,0.00003228164,0.00004907293,0.0001085343,0.00004340303],"category_scores_gemma":[0.00008389657,0.0001340546,0.00006131196,0.00003002934,0.0001672498,0.000003261149,0.00008521998,0.00004523256,0.000003722623],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006021797,"about_ca_system_score_gemma":0.0000762785,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000479732,"about_ca_topic_score_gemma":0.00002879946,"domain_scores_codex":[0.9990811,0.00002549811,0.0001726678,0.0004116285,0.0001170154,0.0001921377],"domain_scores_gemma":[0.9992924,0.000005465794,0.0001002865,0.0003454989,0.0000971831,0.0001591542],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001443035,0.00003187128,0.0689946,0.00003982112,0.00003579096,0.00009107065,0.00003369065,0.000002808308,0.8802904,0.000001959379,0.04839742,0.001936223],"study_design_scores_gemma":[0.000273725,0.0004223322,0.6812249,0.00001195468,0.00007662599,0.0002147512,0.0001402751,0.00001842666,0.2870969,0.0003931328,0.02985794,0.0002690807],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9887236,0.003045521,0.0001266846,0.0000204989,0.0004478591,0.0001329271,0.00001329801,0.00001881614,0.007470775],"genre_scores_gemma":[0.9956224,0.00004136543,0.0001532896,0.0002461763,0.0004989695,0.000009308471,0.0002198929,0.00001717688,0.00319142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6122302,"threshold_uncertainty_score":0.5466588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005962143400015697,"score_gpt":0.2194516709366778,"score_spread":0.2134895275366621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}