{"id":"W2785095220","doi":"10.1016/j.celrep.2017.12.083","title":"CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function","year":2018,"lang":"en","type":"article","venue":"Cell Reports","topic":"Genetic and Kidney Cyst Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute; Simon Fraser University","funders":"Eshelman Institute for Innovation, University of North Carolina at Chapel Hill; Merck Sharp and Dohme; Janssen Biotech; Canadian Institutes of Health Research; Innovative Medicines Initiative; Michael Smith Health Research BC; Wellcome Trust; Mount Sylvia Diatomite; Novartis Pharma; Canada Foundation for Innovation; Ontario Ministry of Economic Development and Innovation; Genome Canada; Boehringer Ingelheim; Pfizer UK; Merck KGaA; AbbVie; Takeda Pharmaceutical Company; Pfizer","keywords":"Kinase; Function (biology); Protein-Serine-Threonine Kinases; Cilium; Biology; Cell biology; Genetics; Computational biology; Protein kinase A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001181417,0.0002994436,0.0002360194,0.0002628694,0.0004605916,0.0006036907,0.0002146547,0.0002759618,0.0009561113],"category_scores_gemma":[0.0002243092,0.000143406,0.0002467264,0.0002353217,0.0004528482,0.0003709617,0.000317852,0.0004601318,0.0005141486],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008446536,"about_ca_system_score_gemma":0.0004453383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001884757,"about_ca_topic_score_gemma":0.002301434,"domain_scores_codex":[0.9999378,0.000005626186,0.000005066884,0.00002098976,0.00001718717,0.00001336964],"domain_scores_gemma":[0.9999361,0.000007996462,0.00001885728,0.000008011645,0.00001103388,0.00001799884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005827633,0.00004669903,0.01218904,0.0004369017,0.00006340023,0.001117106,0.0001778483,0.003052272,0.920691,0.01058915,0.001256977,0.04979672],"study_design_scores_gemma":[0.0001165943,0.0001587081,0.05051481,0.00004166329,0.000088243,0.008293403,0.0002214235,0.01040317,0.8154283,0.002830641,0.1117931,0.0001100229],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9512704,0.01558014,0.01755548,0.0008531699,0.0001646616,0.00005253934,0.001304642,0.0003247312,0.01289414],"genre_scores_gemma":[0.9836925,0.003617248,0.008601394,0.0001259814,0.00001973989,0.00002259342,0.0007817324,0.00003061283,0.003108242],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001884757,"threshold_uncertainty_score":0.00612843,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005962143400015697,"score_gpt":0.2194516709366778,"score_spread":0.2134895275366621,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}