{"id":"W2785190631","doi":"10.1182/blood.v130.suppl_1.2545.2545","title":"Importance of Mitochondrial Metabolism As a Selective Therapeutic Approach in Chronic Lymphocytic Leukemia Patients","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"","keywords":"Chronic lymphocytic leukemia; Bioenergetics; Mitochondrion; Cancer research; Oligomycin; NAD+ kinase; Biology; Reactive oxygen species; Cancer cell; Inner mitochondrial membrane; Viability assay; Leukemia; Biochemistry; Apoptosis; Chemistry; Cancer; Immunology; Enzyme; ATPase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003076099,0.000316319,0.000283227,0.0003211109,0.000249554,0.0004178506,0.0001510343,0.000222934,0.001454833],"category_scores_gemma":[0.000310609,0.00004094921,0.000170525,0.0003312237,0.0001406086,0.0002496887,0.0002803868,0.0002507183,0.0002007167],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004957079,"about_ca_system_score_gemma":0.0002883713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003138171,"about_ca_topic_score_gemma":0.0009097469,"domain_scores_codex":[0.9998493,0.00004378427,0.00001933879,0.0000264268,0.00003140948,0.00002971981],"domain_scores_gemma":[0.9998691,0.00001805913,0.00005157423,0.000006628319,0.00002440049,0.0000301135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.007086891,0.0005483652,0.1919813,0.00140045,0.0002155867,0.001438001,0.0003656176,0.0009644078,0.2331042,0.0008766645,0.003692621,0.5583258],"study_design_scores_gemma":[0.001094915,0.01212804,0.7208263,0.0007410594,0.0007757694,0.01226578,0.0009210837,0.003303574,0.1371931,0.001868252,0.1088236,0.00005848082],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9125417,0.07345997,0.003419085,0.001522033,0.0001014049,0.0001526575,0.0006889969,0.0001567344,0.007957443],"genre_scores_gemma":[0.9898726,0.006622729,0.001570447,0.0003469539,0.00006296862,0.00008908804,0.000495091,0.000009114041,0.0009309945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001454833,"threshold_uncertainty_score":0.004866898,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01034785740113319,"score_gpt":0.2656714839553813,"score_spread":0.2553236265542481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}