{"id":"W2785190631","doi":"10.1182/blood.v130.suppl_1.2545.2545","title":"Importance of Mitochondrial Metabolism As a Selective Therapeutic Approach in Chronic Lymphocytic Leukemia Patients","year":2017,"lang":"en","type":"article","venue":"Blood","topic":"Biochemical and Molecular Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Research Institute in Oncology and Hematology; CancerCare Manitoba","funders":"","keywords":"Chronic lymphocytic leukemia; Bioenergetics; Mitochondrion; Cancer research; Oligomycin; NAD+ kinase; Biology; Reactive oxygen species; Cancer cell; Inner mitochondrial membrane; Viability assay; Leukemia; Biochemistry; Apoptosis; Chemistry; Cancer; Immunology; Enzyme; ATPase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008199675,0.0001458176,0.0001988408,0.00003657425,0.00007515067,0.00002506862,0.0004546598,0.0001685002,0.000005275861],"category_scores_gemma":[0.0001229212,0.0001299746,0.0001051076,0.00006002931,0.0001571846,0.000005145015,0.0001968206,0.0001229661,0.000004779448],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001543284,"about_ca_system_score_gemma":0.000941825,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001750257,"about_ca_topic_score_gemma":0.00003939711,"domain_scores_codex":[0.9988659,0.00004793286,0.0001963849,0.0003889922,0.0002009767,0.0002998382],"domain_scores_gemma":[0.9990978,0.000005111246,0.0001320982,0.0005960246,0.00009724493,0.00007167446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001645929,0.0001751363,0.007154407,0.00003881807,0.0001193399,0.000003561255,0.00002586766,0.00001068541,0.9913558,0.00009166856,0.00006635868,0.0007937078],"study_design_scores_gemma":[0.005232692,0.0002631975,0.02736977,0.0000139196,0.00004279201,0.000005962508,0.000005804813,0.00006455817,0.9659435,0.0001979663,0.0006852338,0.0001746534],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9949219,0.001615037,0.00005755408,0.00000878939,0.00005119584,0.0003096898,0.00001165316,0.000004575208,0.003019623],"genre_scores_gemma":[0.9990656,0.0001215124,0.0002867091,0.00005473195,0.0001638678,0.00005807066,0.00005914327,0.00002063265,0.000169704],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02541241,"threshold_uncertainty_score":0.5300211,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01034785740113319,"score_gpt":0.2656714839553813,"score_spread":0.2553236265542481,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}