{"id":"W2785195392","doi":"10.1172/jci97650","title":"iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling","year":2018,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Cytokine Signaling Pathways and Interactions","field":"Medicine","cited_by":97,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"National Institute of General Medical Sciences; Weill Cornell Medical College; Hospital for Special Surgery; Lupus Research Alliance; National Institutes of Health; Lupus Research Institute; Universiteit van Amsterdam; Amgen","keywords":"Lupus nephritis; Kidney; Cancer research; Tumor necrosis factor alpha; Pathogenesis; Signal transduction; Kidney disease; Biology; Immunology; Internal medicine; Endocrinology; Medicine; Cell biology; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001961439,0.0003013567,0.0002960023,0.0002337963,0.0001534033,0.0003742099,0.0001393027,0.0002938179,0.001487413],"category_scores_gemma":[0.00008852651,0.0001263211,0.0002003406,0.0001404232,0.000235412,0.0001581793,0.0002245746,0.0008673634,0.0003799592],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001683322,"about_ca_system_score_gemma":0.0001751221,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001505025,"about_ca_topic_score_gemma":0.0004060982,"domain_scores_codex":[0.9998063,0.00003977595,0.00001743019,0.0000346019,0.00005130624,0.00005066162],"domain_scores_gemma":[0.999899,0.000005815782,0.00003452181,0.000009081752,0.000008168976,0.00004323346],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007108707,0.0001355258,0.001459435,0.000107246,0.00001328067,0.0001927681,0.00002153959,0.00005260867,0.99421,0.00008904393,0.0001685363,0.002839081],"study_design_scores_gemma":[0.0002304155,0.002091889,0.05385818,0.00004293054,0.00009458434,0.002797423,0.000144076,0.001333407,0.9273256,0.0001838447,0.01188439,0.00001325419],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922002,0.003471673,0.00127226,0.000208277,0.00003958452,0.00003043317,0.0003679151,0.000146873,0.002262755],"genre_scores_gemma":[0.9951826,0.001035514,0.0007661661,0.0001010097,0.00002383039,0.00003750952,0.0003999234,0.00001332844,0.002440116],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001487413,"threshold_uncertainty_score":0.004975855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1195552076462973,"score_gpt":0.4036287750175839,"score_spread":0.2840735673712866,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}