{"id":"W2785293290","doi":"10.1073/pnas.1714446115","title":"Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Sunnybrook Health Science Centre","funders":"National Eye Institute; Japan Society for the Promotion of Science; Robert H. Lurie Comprehensive Cancer Center; National Cancer Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Mallinckrodt Pharmaceuticals; Northwestern University","keywords":"Endothelium; Angiopoietin receptor; Agonist; Receptor; Receptor tyrosine kinase; Context (archaeology); Lymphatic Endothelium; Cell biology; Angiopoietin; Biology; Lymphatic system; Pharmacology; Cancer research; Signal transduction; Immunology; Endocrinology; Biochemistry; Vascular endothelial growth factor; VEGF receptors","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008507705,0.0001612036,0.0001237634,0.0001172625,0.000105167,0.000437086,0.0001139242,0.0001394922,0.0008027966],"category_scores_gemma":[0.0001798489,0.0001431419,0.00009997358,0.00007856972,0.0001900029,0.0002622358,0.0002136937,0.0003266923,0.0001937938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002433256,"about_ca_system_score_gemma":0.0001255187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002854344,"about_ca_topic_score_gemma":0.0005771866,"domain_scores_codex":[0.999912,0.00001391462,0.000005545964,0.00002407169,0.00002159084,0.00002282834],"domain_scores_gemma":[0.9999255,0.00001306018,0.00002446219,0.000006068692,0.000007817796,0.00002307861],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006729079,0.000004100699,0.0003364129,0.000008456064,0.000002077648,0.00003864664,0.000005692595,0.00006439575,0.998386,0.0002291159,0.00001262409,0.0008453202],"study_design_scores_gemma":[0.00001014416,0.00006691648,0.009630999,0.000003529045,0.00001015524,0.0005202917,0.00003114681,0.002244542,0.9848778,0.0002387154,0.002361032,0.000004902435],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934337,0.001259064,0.003594857,0.00005131892,0.00001171573,0.000005651705,0.00012492,0.00003035322,0.001488423],"genre_scores_gemma":[0.9974959,0.0004425411,0.0008096527,0.00001481283,0.000003398289,0.000006428108,0.00009857053,0.000009359123,0.001119218],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008027966,"threshold_uncertainty_score":0.002685606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02600144792055907,"score_gpt":0.2895072395813447,"score_spread":0.2635057916607856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}