{"id":"W2785293290","doi":"10.1073/pnas.1714446115","title":"Context-dependent functions of angiopoietin 2 are determined by the endothelial phosphatase VEPTP","year":2018,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":132,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; Sunnybrook Health Science Centre","funders":"National Eye Institute; Japan Society for the Promotion of Science; Robert H. Lurie Comprehensive Cancer Center; National Cancer Institute; National Institutes of Health; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Mallinckrodt Pharmaceuticals; Northwestern University","keywords":"Endothelium; Angiopoietin receptor; Agonist; Receptor; Receptor tyrosine kinase; Context (archaeology); Lymphatic Endothelium; Cell biology; Angiopoietin; Biology; Lymphatic system; Pharmacology; Cancer research; Signal transduction; Immunology; Endocrinology; Biochemistry; Vascular endothelial growth factor; VEGF receptors","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005472614,0.00006811273,0.00009139495,0.00002556524,0.0001607004,0.000008427175,0.0005244888,0.00006398306,0.00002612548],"category_scores_gemma":[0.0001895696,0.0000388451,0.0001089995,0.0001699373,0.001043828,0.00001140427,0.0001163434,0.00004031604,0.000001167638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007439213,"about_ca_system_score_gemma":0.00003354737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001440346,"about_ca_topic_score_gemma":6.568421e-7,"domain_scores_codex":[0.9990771,0.000005744103,0.000197511,0.0001726145,0.0004471207,0.00009984916],"domain_scores_gemma":[0.9993336,0.00002307188,0.0003308315,0.00001487453,0.0002780638,0.00001958763],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005004347,0.0000364214,0.005973126,0.00001293571,0.00003499209,1.334917e-9,0.00003830452,0.000004990218,0.9693793,0.00113683,0.02232689,0.001006182],"study_design_scores_gemma":[0.000167596,0.0001065125,0.005022993,0.00002001933,0.00001684597,0.000003876534,0.0002175309,0.00002527488,0.9823175,0.0004005241,0.01165285,0.00004848657],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994194,0.00227639,0.000008395114,0.001235871,0.00005147096,0.0001520572,0.0002960816,0.000002608309,0.001783141],"genre_scores_gemma":[0.9988313,0.00006152995,0.00007825917,0.0003545377,0.0001933137,0.00001137697,7.636823e-7,0.000003373815,0.0004655897],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0129382,"threshold_uncertainty_score":0.3846029,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02600144792055907,"score_gpt":0.2895072395813447,"score_spread":0.2635057916607856,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}