{"id":"W2785307285","doi":"10.1016/j.abb.2011.11.017","title":"Ser-796 of β-galactosidase (Escherichia coli) plays a key role in maintaining a balance between the opened and closed conformations of the catalytically important active site loop","year":2011,"lang":"en","type":"article","venue":"Archives of Biochemistry and Biophysics","topic":"Carbohydrate Chemistry and Synthesis","field":"Chemistry","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Chemistry; Stereochemistry; Escherichia coli; Loop (graph theory); Substrate (aquarium); Active site; Catalysis; Covalent bond; Hydrophobic effect; Crystallography; Biochemistry; Organic chemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003160052,0.0004347154,0.0004218851,0.0001656814,0.0003392305,0.0007782706,0.0005093169,0.0004319159,0.002000334],"category_scores_gemma":[0.0004122581,0.0002264411,0.0002471647,0.0001401242,0.0005796954,0.0008028754,0.0003896475,0.000667484,0.001569286],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003331793,"about_ca_system_score_gemma":0.0002571376,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001985023,"about_ca_topic_score_gemma":0.0001643833,"domain_scores_codex":[0.9998088,0.00003237951,0.00001674558,0.00004324511,0.00006726297,0.0000316052],"domain_scores_gemma":[0.9997409,0.00005721351,0.00005428047,0.00001887594,0.00001916725,0.0001095944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007829076,0.00006933703,0.0008509987,0.00008700479,0.00001382787,0.0002765183,0.00007090101,0.000337532,0.9867411,0.00134324,0.0002427356,0.009183831],"study_design_scores_gemma":[0.00004411941,0.0002105895,0.00266537,0.00001138841,0.0000132793,0.0007307362,0.00006269376,0.002011761,0.9892658,0.0006186384,0.004347788,0.00001775141],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9852465,0.001487595,0.008932171,0.0002593541,0.0001425876,0.00002128249,0.0001792763,0.0002557682,0.003475381],"genre_scores_gemma":[0.9948264,0.0004016271,0.002851032,0.00009271278,0.00002601299,0.000005689641,0.000231705,0.00005861442,0.001506283],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002000334,"threshold_uncertainty_score":0.006691754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009513578598375337,"score_gpt":0.1995035205300882,"score_spread":0.1899899419317129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}