{"id":"W2785318676","doi":"10.1101/238733","title":"CYRI1-mediated inhibition of RAC1 signalling restricts <i>Salmonella</i> Typhimurium infection","year":2017,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Salmonella and Campylobacter epidemiology","field":"Agricultural and Biological Sciences","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; McGill University; McGill Genome Centre; Armand Frappier Museum; McGill University Health Centre","funders":"Fonds de Recherche du Québec - Santé; Deutsche Forschungsgemeinschaft; Canadian Institutes of Health Research; European Commission","keywords":"Salmonella; RAC1; Effector; Biology; Cell biology; Actin cytoskeleton; Pathogenicity island; Actin; Microbiology; Signal transduction; Cytoskeleton; Cell; Bacteria; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001866766,0.0002668773,0.0002564158,0.0001649091,0.0001572357,0.0003536806,0.0002546442,0.0002819324,0.002969386],"category_scores_gemma":[0.0001238608,0.0001263096,0.000242888,0.00007607629,0.0002270354,0.0001183594,0.0002271088,0.0006276009,0.0009695953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003944556,"about_ca_system_score_gemma":0.0003253449,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001249513,"about_ca_topic_score_gemma":0.001279001,"domain_scores_codex":[0.9998527,0.00002463562,0.000009807993,0.00003245371,0.00003115,0.0000493657],"domain_scores_gemma":[0.999913,0.00001758481,0.00002030845,0.00001125908,0.00001153358,0.00002640157],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001083965,0.00002331557,0.00008425022,0.00002948213,0.000002982242,0.000014886,0.000006406164,0.00007659585,0.9985518,0.0001242669,0.0001759142,0.0008016631],"study_design_scores_gemma":[0.00001303094,0.0001464407,0.002015062,0.00000585785,0.000004827303,0.000070027,0.00001692118,0.001416891,0.9924147,0.00003057261,0.003862338,0.000003403345],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867113,0.001345801,0.003990154,0.0004309678,0.00007476367,0.00004324844,0.0009958532,0.0003387008,0.006069083],"genre_scores_gemma":[0.9888085,0.0005422347,0.003225238,0.0001564445,0.00001518446,0.00003362333,0.0010655,0.00009328214,0.006059912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002969386,"threshold_uncertainty_score":0.009933591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02648750629113937,"score_gpt":0.224036933066153,"score_spread":0.1975494267750137,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}