{"id":"W2785353872","doi":"10.1016/j.chom.2017.12.018","title":"Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium","year":2018,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Army Research Office; Natural Sciences and Engineering Research Council of Canada; Intelligence Advanced Research Projects Activity; Cancerfonden; National Institutes of Health; Vetenskapsrådet; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Office of the Director of National Intelligence; Intellectual and Developmental Disabilities Research Center; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Boston Children's Hospital; Wenner-Gren Foundation; Burroughs Wellcome Fund; Foundation for the National Institutes of Health","keywords":"Biology; Enterococcus faecium; Microbiology; Toxin; Clostridium botulinum; Botulism; Gene cluster; Gene; Plasmid; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002143062,0.0001824724,0.0004001127,0.0001712719,0.00003009658,0.000007280728,0.0001940439,0.0002246506,0.0002030807],"category_scores_gemma":[0.00004888137,0.0001583606,0.0001421672,0.0003670228,0.0003694532,0.00004300714,0.00008114144,0.0003418787,0.00006900931],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000215094,"about_ca_system_score_gemma":0.00004697394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002378004,"about_ca_topic_score_gemma":0.00001800291,"domain_scores_codex":[0.9983612,0.00010372,0.0007339465,0.000345694,0.00016322,0.0002921953],"domain_scores_gemma":[0.9990703,0.00006555025,0.0002679978,0.0003895476,0.0001128631,0.00009377706],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003557832,0.0008645074,0.006659089,0.0001435541,0.00001717291,0.00002305584,0.0005263297,0.000002423719,0.9896384,0.00001538506,0.001310787,0.0004434859],"study_design_scores_gemma":[0.003976296,0.001310193,0.06514806,0.0001241232,0.00006986683,0.00002619871,0.0002654874,0.0002130649,0.925378,0.00008550282,0.003219784,0.0001834408],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963753,0.0002458045,0.0002146824,0.0007954565,0.0002826767,0.0006912297,0.00004807804,0.00003233285,0.001314498],"genre_scores_gemma":[0.9977641,0.0001257967,0.0001112553,0.001221077,0.00003962932,0.00001241302,0.00002393579,0.00002548583,0.0006762809],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06426044,"threshold_uncertainty_score":0.6457759,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01166816799292114,"score_gpt":0.2581168927746471,"score_spread":0.2464487247817259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}