{"id":"W2785353872","doi":"10.1016/j.chom.2017.12.018","title":"Identification of a Botulinum Neurotoxin-like Toxin in a Commensal Strain of Enterococcus faecium","year":2018,"lang":"en","type":"article","venue":"Cell Host & Microbe","topic":"Botulinum Toxin and Related Neurological Disorders","field":"Medicine","cited_by":157,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Waterloo","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institute of Allergy and Infectious Diseases; Army Research Office; Natural Sciences and Engineering Research Council of Canada; Intelligence Advanced Research Projects Activity; Cancerfonden; National Institutes of Health; Vetenskapsrådet; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Office of the Director of National Intelligence; Intellectual and Developmental Disabilities Research Center; Eunice Kennedy Shriver National Institute of Child Health and Human Development; Boston Children's Hospital; Wenner-Gren Foundation; Burroughs Wellcome Fund; Foundation for the National Institutes of Health","keywords":"Biology; Enterococcus faecium; Microbiology; Toxin; Clostridium botulinum; Botulism; Gene cluster; Gene; Plasmid; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002078516,0.000523337,0.0004180867,0.0005925439,0.0005238361,0.0007764206,0.0003717992,0.0008249112,0.0005603581],"category_scores_gemma":[0.000997426,0.0002339999,0.0006573416,0.0005947273,0.0003290865,0.0003030849,0.0006103276,0.0005804905,0.0003916953],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002932056,"about_ca_system_score_gemma":0.0003972559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003514346,"about_ca_topic_score_gemma":0.002258142,"domain_scores_codex":[0.9996513,0.00004740381,0.00004806406,0.00007338491,0.00009745191,0.00008234206],"domain_scores_gemma":[0.9993292,0.0001407527,0.0001185615,0.00006580051,0.0001929688,0.0001527764],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005150051,0.0003045777,0.01633379,0.00007427953,0.00004028238,0.005975203,0.0003838165,0.0001468135,0.9736952,0.000155833,0.0001319296,0.002243275],"study_design_scores_gemma":[0.0001074689,0.004221164,0.3245314,0.00008219771,0.0003139173,0.04746881,0.004109668,0.002411301,0.6113002,0.000276919,0.005102698,0.00007415802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981463,0.0001171346,0.0005396816,0.0001016283,0.00005319563,0.000038502,0.000397197,0.000008496346,0.0005977938],"genre_scores_gemma":[0.9964476,0.0001308961,0.00162334,0.0001067934,0.00001982756,0.00001686173,0.0007161535,0.00001096729,0.0009275646],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003514346,"threshold_uncertainty_score":0.00698781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01166816799292114,"score_gpt":0.2581168927746471,"score_spread":0.2464487247817259,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}