{"id":"W2785387202","doi":"10.1136/bmj.k226","title":"Research ethics for emerging trial designs: does equipoise need to adapt?","year":2018,"lang":"en","type":"article","venue":"BMJ","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital; University of Ottawa; Western University","funders":"","keywords":"Research ethics; Computer science; Clinical equipoise; Data science; Research design; Engineering ethics; World Wide Web; Medicine; Clinical trial; Sociology; Pathology; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch","research_integrity"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.8078231,0.00151446,0.006446749,0.003399795,0.009210449,0.02918158,0.009885721,0.04589492,0.005476422],"category_scores_gemma":[0.8745859,0.002685333,0.005711117,0.002985776,0.07894116,0.04453532,0.02196207,0.08619367,0.003217289],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01093758,"about_ca_system_score_gemma":0.04649282,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00243261,"about_ca_topic_score_gemma":0.004543092,"domain_scores_codex":[0.1540629,0.7115543,0.05478097,0.01504372,0.0588905,0.005667571],"domain_scores_gemma":[0.03757432,0.851431,0.01984014,0.04647044,0.03730759,0.007376494],"domain_codex":"methods","domain_gemma":"methods","domain_candidate":"methods","domain_consensus":"methods","study_design_codex":"design_other","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0008332509,0.0005648455,0.009422095,0.008559531,0.00215033,0.001464746,0.05557071,0.00197892,0.001008539,0.3267583,0.1834642,0.4082245],"study_design_scores_gemma":[0.001089097,0.000936952,0.004029788,0.02098278,0.0005920019,0.00283296,0.01164014,0.002995834,0.0009706632,0.708924,0.2443171,0.0006886913],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.002617526,0.01565052,0.04151502,0.9235902,0.0103425,0.0004587688,0.0000411904,0.0001497566,0.00563453],"genre_scores_gemma":[0.09925946,0.008914954,0.1112185,0.7577142,0.01759769,0.003378547,0.00007654593,0.0004931181,0.001346995],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.9541051,"threshold_uncertainty_score":0.2369884,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.903629429434826,"score_gpt":0.7374030767892167,"score_spread":0.1662263526456094,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}