{"id":"W2785434445","doi":"10.3791/56904","title":"Simple Generation of a High Yield Culture of Induced Neurons from Human Adult Skin Fibroblasts","year":2018,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Medical Research Council; Parkinsonfonden; Horizon 2020 Framework Programme; Lunds Universitet; Vetenskapsrådet; University of Cambridge; Canadian Institutes of Health Research; National Institute for Health and Care Research; European Commission; New York Stem Cell Foundation","keywords":"Reprogramming; Cell culture; Cell sorting; Cell biology; Somatic cell; Cell; Biology; Computer science; Chemistry; Computational biology; Biomedical engineering; Neuroscience; Pathology; Medicine; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004478453,0.0005704321,0.0004021636,0.0004163526,0.000406292,0.0005825548,0.000566333,0.0004011073,0.003289018],"category_scores_gemma":[0.0003227401,0.0003032454,0.0004808341,0.0003291649,0.0002060078,0.000258389,0.0005220757,0.001011429,0.003131212],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002076945,"about_ca_system_score_gemma":0.0004177042,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005757199,"about_ca_topic_score_gemma":0.001559156,"domain_scores_codex":[0.9996118,0.00002603379,0.00007836701,0.00008518998,0.0001625305,0.00003611498],"domain_scores_gemma":[0.9997959,0.00003701111,0.00002243446,0.00005647919,0.00005868646,0.00002963242],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003613409,0.00003602697,0.0001967463,0.0001293393,0.000008040665,0.0003173073,0.00006339715,0.0001605781,0.9914616,0.0005299443,0.0005819545,0.006478917],"study_design_scores_gemma":[0.00002202771,0.0001580967,0.001484525,0.00005292091,0.00003372884,0.0008346182,0.00003963321,0.0008848317,0.9662082,0.0002197766,0.03004383,0.00001777382],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"methods","genre_scores_codex":[0.3953391,0.007525766,0.5049189,0.0006173503,0.001168324,0.004574461,0.02362418,0.003445585,0.05878628],"genre_scores_gemma":[0.5585275,0.01091588,0.3715741,0.0003949017,0.0001518811,0.003877195,0.01945296,0.0007119873,0.03439355],"genre_candidate":"methods","genre_consensus":"methods","teacher_disagreement_score":0.003289018,"threshold_uncertainty_score":0.01100284,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04469584415104878,"score_gpt":0.4076747395871924,"score_spread":0.3629788954361436,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}