{"id":"W2785441464","doi":"10.1038/aps.2018.11","title":"Proteostasis in Huntington's disease: disease mechanisms and therapeutic opportunities","year":2018,"lang":"en","type":"review","venue":"Acta Pharmacologica Sinica","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":109,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Fundação de Amparo à Pesquisa do Estado de São Paulo; Novartis Pharma; Wellcome Trust; Ontario Genomics Institute; European Federation of Pharmaceutical Industries and Associations; Merck KGaA; Genome Canada; Ontario Genomics; Natural Sciences and Engineering Research Council of Canada; Pfizer","keywords":"Proteostasis; Proteasome; Autophagy; Protein aggregation; Biology; Ubiquitin; Huntington's disease; Disease; Cell biology; Mechanism (biology); Neuroscience; Medicine; Biochemistry; Apoptosis; Pathology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003756259,0.000911269,0.001383076,0.0003484085,0.000322293,0.0002099088,0.00107708,0.0001804658,0.0008503174],"category_scores_gemma":[0.001160928,0.0007112981,0.0004269556,0.0004952662,0.0007127022,0.0001494739,0.000723385,0.0005379958,0.0000778406],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008563897,"about_ca_system_score_gemma":0.000897588,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001553783,"about_ca_topic_score_gemma":6.990085e-7,"domain_scores_codex":[0.9939268,0.002082354,0.0008827117,0.001777471,0.0005299681,0.0008007302],"domain_scores_gemma":[0.9964606,0.001228069,0.0006136891,0.0007260102,0.00006521167,0.0009064298],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005108978,0.002181896,0.00003788016,0.01477434,0.0001720821,0.00113772,0.00009235283,0.000002707026,0.006204316,0.00212475,0.005439464,0.9673216],"study_design_scores_gemma":[0.0004820244,0.000184677,0.0001329689,0.001580731,0.001373982,0.000006220215,0.00001334839,0.00002944378,0.001924234,0.0009996173,0.9923114,0.0009613431],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.004884081,0.9882204,0.00000493808,0.0008742333,0.0005363846,0.004074807,0.000779242,0.0002209148,0.0004050091],"genre_scores_gemma":[0.03439642,0.9601109,0.00007687839,0.002959586,0.0001919811,0.001639113,0.00004226808,0.0001178254,0.0004650394],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.986872,"threshold_uncertainty_score":0.9995338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2344543987760917,"score_gpt":0.3954378708915041,"score_spread":0.1609834721154124,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}