{"id":"W2785529934","doi":"10.1158/1535-7163.targ-17-b181","title":"Abstract B181: The Chk1 inhibitor, SRA737, demonstrates chemical synthetic lethality with replication stress-inducing agents, including low-dose gemcitabine, in preclinical models of cancer","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sierra Wireless (Canada)","funders":"","keywords":"Gemcitabine; Cisplatin; Synthetic lethality; Cancer research; DNA damage; Topoisomerase; Biology; Cancer cell; Mitomycin C; Cancer; DNA replication; DNA repair; CHEK1; Cell cycle; Pharmacology; Cell cycle checkpoint; In vitro; DNA; Biochemistry; Genetics; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005040878,0.000294525,0.0002952164,0.00004825072,0.00008369079,0.00003153769,0.0004592537,0.0002794797,0.00002246303],"category_scores_gemma":[0.00004393425,0.0002297233,0.0001222584,0.0002366089,0.0003615705,0.00001447626,0.0001736846,0.0002872348,0.000001317049],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009723438,"about_ca_system_score_gemma":0.000332071,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005557513,"about_ca_topic_score_gemma":0.0005546169,"domain_scores_codex":[0.9978332,0.0001276719,0.0005320362,0.0007549398,0.0003520859,0.0004000977],"domain_scores_gemma":[0.9982473,0.00003879513,0.0003080876,0.001091131,0.0002358406,0.00007880798],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002671709,0.000184596,0.004845209,0.00006677552,0.0002041721,0.000004597373,0.0001957462,0.001615573,0.9816869,0.000140784,0.00001084818,0.01077762],"study_design_scores_gemma":[0.0007083041,0.0001562405,0.002834455,0.0002648589,0.00009868573,0.000004535712,0.00009078856,0.004058538,0.9907738,0.0004714228,0.0002534775,0.000284913],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937074,0.002520543,0.002271919,0.0004703026,0.0001316382,0.0005161737,0.00005346501,0.00002361012,0.0003049058],"genre_scores_gemma":[0.9977896,0.0005093268,0.0006230559,0.0005856329,0.0001929246,0.0001845414,0.00003384662,0.00006273054,0.00001829319],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01049271,"threshold_uncertainty_score":0.9367844,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05506971729150969,"score_gpt":0.3484874899095117,"score_spread":0.2934177726180021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}