{"id":"W2785529934","doi":"10.1158/1535-7163.targ-17-b181","title":"Abstract B181: The Chk1 inhibitor, SRA737, demonstrates chemical synthetic lethality with replication stress-inducing agents, including low-dose gemcitabine, in preclinical models of cancer","year":2018,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Sierra Wireless (Canada)","funders":"","keywords":"Gemcitabine; Cisplatin; Synthetic lethality; Cancer research; DNA damage; Topoisomerase; Biology; Cancer cell; Mitomycin C; Cancer; DNA replication; DNA repair; CHEK1; Cell cycle; Pharmacology; Cell cycle checkpoint; In vitro; DNA; Biochemistry; Genetics; Chemotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001591626,0.0007374304,0.0004489509,0.0006052281,0.0002743202,0.0003055985,0.0002925316,0.0003381628,0.002970278],"category_scores_gemma":[0.00009309212,0.0001775813,0.0002663958,0.000308204,0.0002377889,0.0002344555,0.000134985,0.000999545,0.0005547862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003728846,"about_ca_system_score_gemma":0.0005500095,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001628485,"about_ca_topic_score_gemma":0.003033173,"domain_scores_codex":[0.9998279,0.00002779762,0.00001427603,0.00002381546,0.00005621688,0.00004994671],"domain_scores_gemma":[0.999869,0.00001475085,0.00003120215,0.0000130617,0.0000155707,0.00005629784],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001312614,0.0009428281,0.0003186954,0.0001069654,0.0000339828,0.0000652501,0.00002047492,0.0004469533,0.98696,0.0002791604,0.001018302,0.008494793],"study_design_scores_gemma":[0.00009279606,0.00401742,0.001615116,0.00000856576,0.00004000396,0.0001411305,0.00001467368,0.0008758545,0.9907339,0.00003631826,0.002419086,0.00000505905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986829,0.003357356,0.002242151,0.0003244979,0.0001158567,0.0001188029,0.001625887,0.0004807753,0.004905563],"genre_scores_gemma":[0.990159,0.001738147,0.001780601,0.00007635827,0.00002338428,0.0001169798,0.001581482,0.00004871852,0.004475494],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002970278,"threshold_uncertainty_score":0.009936571,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05506971729150969,"score_gpt":0.3484874899095117,"score_spread":0.2934177726180021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}